GCH1

Gene Symbol	GCH1
Entrez Gene	2643
Alt Symbol	DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Species	Human
Gene Type	protein-coding
Description	GTP cyclohydrolase 1
Other Description	GTP cyclohydrolase I|GTP-CH-I|dystonia 14|guanosine 5'-triphosphate cyclohydrolase I
Swissprots	Q9Y4I8 P30793 Q6FHY7
Accessions	AAB42186 AAB60633 CAA83213 EAW80647 EAW80648 EAW80649 EAW80650 EAW80651 EAW80652 EAW80653 P30793 AF321276 AAK51704 AY137463 AAN17459 AY137464 AAN17460 AY137465 AAN17461 BC025415 AAH25415 BM971258 CR536551 CAG38788 DQ892998 ABM83924 DQ896245 ABM87244 S43856 AAB23166 S44049 AAB23164 S44053 AAB23165 U19523 AAB16861 U66095 AAD38866 U66097 AAD38868 Z16418 CAA78908 Z29433 CAB77391 Z29434 CAB77392 XM_005267530 XP_005267587 XM_011536643 XP_011534945 NM_000161 NP_000152 NM_001024024 NP_001019195 NM_001024070 NP_001019241 NM_001024071 NP_001019242
Function	Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16338639, ECO:0000269|PubMed:17057711, ECO:0000269|PubMed:8068008, ECO:0000269|PubMed:9445252}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269|PubMed:16778797}.
Top Pathways	Folate biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GCH1 (Human) IP-WB Antibody Pair - H00002643-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

GCH1 (Human) Matched Antibody Pair - H00002643-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human GCH1 ELISA Kit - HG0032 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine GCH1 ELISA Kit - AG0032 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

GTP cyclohydrolase 1, ELISA Kit - MBS936916 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human GCH1 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

GTP cyclohydrolase 1, ELISA Kit - MBS9310943 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5 triphosphate Cyclohydrolase1, ELISA Kit - MBS725115 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS736773 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS743724 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS726831 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS726082 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS740177 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS732314 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS738729 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS744114 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS743378 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS740330 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanosine 5-triphosphate Cyclohydrolase1, ELISA Kit - MBS724212 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human GTP cyclohydrolase 1(GCH1) ELISA kit - CSB-EL009317HU from Cusabio Category ELISA Kit Sensitivity 5.8pg/ml Range 23.5 pg/ml-1500 pg/ml

Human Guanosine 5-triphosphate Cyclohydrolase1 ELISA - E01G0025 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 pg/ml

Human GTP cyclohydrolase 1 (GCH1) ELISA Kit - EKC33925 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Human GCH1 ELISA Kit - E017693 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human GCH1 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

Human GCH1 ELISA Kit - EHG0032 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

anti-GCH1 antibody - ARG64624 from Arigo Biolaboratories Category ELISA Kit

GCH1 ELISA Kit (Human) (OKCA01270) - OKCA01270 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 5.8 pg/mL Range 23.5 - 1,500 pg/mL

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