GCH1

Gene Symbol	GCH1
Entrez Gene	2643
Alt Symbol	DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Species	Human
Gene Type	protein-coding
Description	GTP cyclohydrolase 1
Other Description	GTP cyclohydrolase I|GTP-CH-I|dystonia 14|guanosine 5'-triphosphate cyclohydrolase I
Swissprots	Q9Y4I8 P30793 Q6FHY7
Accessions	AAB42186 AAB60633 CAA83213 EAW80647 EAW80648 EAW80649 EAW80650 EAW80651 EAW80652 EAW80653 P30793 AF321276 AAK51704 AY137463 AAN17459 AY137464 AAN17460 AY137465 AAN17461 BC025415 AAH25415 BM971258 CR536551 CAG38788 DQ892998 ABM83924 DQ896245 ABM87244 S43856 AAB23166 S44049 AAB23164 S44053 AAB23165 U19523 AAB16861 U66095 AAD38866 U66097 AAD38868 Z16418 CAA78908 Z29433 CAB77391 Z29434 CAB77392 XM_005267530 XP_005267587 XM_011536643 XP_011534945 NM_000161 NP_000152 NM_001024024 NP_001019195 NM_001024070 NP_001019241 NM_001024071 NP_001019242
Function	Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16338639, ECO:0000269|PubMed:17057711, ECO:0000269|PubMed:8068008, ECO:0000269|PubMed:9445252}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269|PubMed:16778797}.
Top Pathways	Folate biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GTP cyclohydrolase 1 peptide - ab109890 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human GTP cyclohydrolase 1 full length protein - ab114820 from Abcam Category Protein Source Wheat germ Species Human

Human GTP cyclohydrolase 1 protein fragment - ab114821 from Abcam Category Protein Source Wheat germ Species Human

GTPCH1 / GCH1 Antibody Blocking Peptide - LS-E7998 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GTPCH1 / GCH1 Antibody Blocking Peptide - LS-E21812 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GTPCH1 / GCH1 Antibody Blocking Peptide - LS-E26627 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GCH1 Protein - H00002643-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human GCH1 Protein - H00002643-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GCH1-Antibody-N-term-Blocking-peptide - BP5839a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GCH1 blocking peptide - GTX88689-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

GTP-CH-1 peptide - orb72770 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Goat anti GCH1 antibody Immunizing peptide - orb50486 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

GCH1 Blocking Peptide - 33R-5373 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GTP Cyclohydrolase 1 Peptide - AC21-1463-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

GTP cyclohydrolase 1 (GCH1) - H00002643-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GTP cyclohydrolase 1 (GCH1) - H00002643-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GTP cyclohydrolase 1 (GCH1) - H00002643-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GTP cyclohydrolase 1 (GCH1) - H00002643-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GTP cyclohydrolase 1 (GCH1) control peptide - AP10097CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

GTP cyclohydrolase 1 (GCH1) control peptide - AP10098CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

GCH1 Peptide - 46-847P from ProSci Category Peptide Species Human

GTP-CH-1 Peptide - 350575 from ABBIOTEC Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human GCH1 - GCH1-28280TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human GCH1 - GCH1-28283TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human GCH1 - GCH1-470H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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