| Gene Symbol |
CCP110
|
| Entrez Gene |
9738
|
| Alt Symbol |
CP110, Cep110
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centriolar coiled coil protein 110kDa
|
| Other Description |
centriolar coiled-coil protein of 110 kDa|centrosomal protein CP110|centrosomal protein of 110 kDa
|
| Swissprots |
Q68DV9 O43335 B7WP23 Q8NE13 O43303
|
| Accessions |
AAC05804 EAW50287 EAW50288 O43303 AB007879 BAA24849 AK300426 BAG62153 AK309196 BC030223 BC034140 BC036654 AAH36654 BP360952 BQ632514 BY798911 CB066937 CN307903 CN307908 CR749255 CAH18111 DA250590 DA370828 DB504255 DQ891266 ABM82192 DQ894454 ABM85380 XM_005255719 XP_005255776 XM_011545991 XP_011544293 XM_011545992 XP_011544294 XM_011545993 XP_011544295 NM_001199022 NP_001185951 NM_014711 NP_055526
|
| Function |
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
|
| Tissue Specificity |
Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:12361598}.
|