Gene Symbol | CCP110 |
---|---|
Entrez Gene | 9738 |
Alt Symbol | CP110, Cep110 |
Species | Human |
Gene Type | protein-coding |
Description | centriolar coiled coil protein 110kDa |
Other Description | centriolar coiled-coil protein of 110 kDa|centrosomal protein CP110|centrosomal protein of 110 kDa |
Swissprots | Q68DV9 O43335 B7WP23 Q8NE13 O43303 |
Accessions | AAC05804 EAW50287 EAW50288 O43303 AB007879 BAA24849 AK300426 BAG62153 AK309196 BC030223 BC034140 BC036654 AAH36654 BP360952 BQ632514 BY798911 CB066937 CN307903 CN307908 CR749255 CAH18111 DA250590 DA370828 DB504255 DQ891266 ABM82192 DQ894454 ABM85380 XM_005255719 XP_005255776 XM_011545991 XP_011544293 XM_011545992 XP_011544294 XM_011545993 XP_011544295 NM_001199022 NP_001185951 NM_014711 NP_055526 |
Function | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis. |
Tissue Specificity | Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:12361598}. |
CP110 CRISPR/Cas9 KO Plasmid (h) - sc-418551 from Santa Cruz Biotechnology
|
||||||||
CP110 HDR Plasmid (h) - sc-418551-HDR from Santa Cruz Biotechnology
|
||||||||
CP110 Double Nickase Plasmid (h) - sc-418551-NIC from Santa Cruz Biotechnology
|
||||||||
CP110 Double Nickase Plasmid (h2) - sc-418551-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CP110 CRISPR Activation Plasmid (h) - sc-418551-ACT from Santa Cruz Biotechnology
|
||||||||
CP110 CRISPR Activation Plasmid (h2) - sc-418551-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CP110 Lentiviral Activation Particles (h) - sc-418551-LAC from Santa Cruz Biotechnology
|
||||||||
CP110 Lentiviral Activation Particles (h2) - sc-418551-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CP110 siRNA (h) - sc-93533 from Santa Cruz Biotechnology
|
||||||||
CP110 shRNA Plasmid (h) - sc-93533-SH from Santa Cruz Biotechnology
|
||||||||
CP110 shRNA (h) Lentiviral Particles - sc-93533-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU007261 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6488 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6488 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11048 from Sigma-Aldrich
|
||||||||
CCP110 siRNA (Human) - CRH6506 from Cohesion Biosciences
|
||||||||
CCP110 - MBS8208834 from MyBioSource
|
||||||||
shRNA set against Human Ccp110 (NM_014711.4) - SHH258097 from Creative biogene
|
||||||||
Human CCP110 siRNA - orb267008 from Biorbyt
|
||||||||
CCP110 shRNA Plasmid (Human) - CHH6506 from Cohesion Biosciences
|