HACD1

Gene Symbol HACD1
Entrez Gene 9200
Alt Symbol CAP, PTPLA
Species Human
Gene Type protein-coding
Description 3-hydroxyacyl-CoA dehydratase 1
Other Description cementum attachment protein|cementum-attachment protein|protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
Swissprots B0YJ81 Q9UHX2 Q96FW7 Q6JIC5 B0YJ80 Q9HB93
Accessions AAG10713 ACA06058 ACA06059 ACA06060 ACA06061 B0YJ81 CAY55982 EAW86210 EAW86211 AF114494 AAF21976 AW022173 AY455942 AAR22554 BC010353 AAH10353 BC027709 HQ447343 ADQ31829 XM_005252641 XP_005252698 XR_428651 NM_014241 NP_055056
Function Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
Subcellular Location Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Tissue Specificity Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). {ECO:0000269|PubMed:11054553, ECO:0000269|PubMed:22067203}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

PTPLA (F-12) - sc-136825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PTPLA (F-12): sc-136825. Western blot analysis of PTPLA expression in Sol8 (A), B16-F0 (B) and M1 (C) whole cell lysates.

PTPLA (M-46) - sc-367387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

cementum attachment protein (3G9) - sc-53947 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cementum attachment protein (3G9): sc-53947. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-PTPLA antibody - ab115950 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PTPLA antibody (ab115950) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-PTPLA antibody - N-terminal - ab192772 from Abcam

Prices $407.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of formalin-fixed, paraffin-embedded human breast tissue labeling PTPLA with ab192772 at a 1/100 dilution.

Anti-HACD1 / PTPLA Antibody (aa36-66, APC) - LS-C239593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66, AP) - LS-C239592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66, Biotin) - LS-C239594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66, FITC) - LS-C239595 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66, PE) - LS-C239597 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66, Azide-free, HRP) - LS-C248581 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa36-66) - LS-C324413 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD1 / PTPLA Antibody (aa37-66) IHC-plus™ - LS-B10947 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-PTPLA antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PTPLA Antibody - NBP2-31903 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: PTPLA Antibody [NBP2-31903] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

Anti-PTPLA antibody produced in rabbit - HPA050901 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PTPLA: <B>Cat. No. HPA050901</B>: Immunohistochemical staining of Human rectum shows strong membranous and cytoplasmic positivity in glandular cells.

ANTI-PTPLA (N-TERM) antibody produced in rabbit - SAB1302650 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>PTPLA (N-term): <B>Cat. No. SAB1302650</B>: PTPLA in Human heart tissue with PTPLA antibody (N-term) at 10 μg/mL.

PTPLA-Antibody-N-term - AP13486a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PTPLA Antibody (N-term) (Cat. #AP13486a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PTPLA antibody detected the PTPLA protein (arrow).

PTPLA Antibody - N-terminal region (OAAB09780) - OAAB09780 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PTPLA antibody - orb31564 from Biorbyt

Prices $60.00, $187.00, $383.00
Sizes 5 μg (Trial size), 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded human heart tissue using PTPLA antibody

PTPLA Antibody - abx027419 from Abbexa

Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human PTPLA (N-term) - 102-12022 from RayBiotech

Host Rabbit

PTPLA antibody (N-term) - STJ43174 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB33378

Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) - MAD612Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) - PAD612Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Anti-PTPLA monoclonal antibody - DCABH-13121 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal
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