HACD1

Gene Symbol	HACD1
Entrez Gene	9200
Alt Symbol	CAP, PTPLA
Species	Human
Gene Type	protein-coding
Description	3-hydroxyacyl-CoA dehydratase 1
Other Description	cementum attachment protein|cementum-attachment protein|protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
Swissprots	B0YJ81 Q9UHX2 Q96FW7 Q6JIC5 B0YJ80 Q9HB93
Accessions	AAG10713 ACA06058 ACA06059 ACA06060 ACA06061 B0YJ81 CAY55982 EAW86210 EAW86211 AF114494 AAF21976 AW022173 AY455942 AAR22554 BC010353 AAH10353 BC027709 HQ447343 ADQ31829 XM_005252641 XP_005252698 XR_428651 NM_014241 NP_055056
Function	Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
Subcellular Location	Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Tissue Specificity	Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). {ECO:0000269|PubMed:11054553, ECO:0000269|PubMed:22067203}.
Top Pathways	Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HACD1 / PTPLA ELISA Kit (Sandwich ELISA) - LS-F8993 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.27 ng/ml Range 0.781-50 ng/ml

protein tyrosine phosphatase-like (proline instead of catalytic arginine) , member A, ELISA Kit - MBS914022 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PTPLA is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.44 pg/ml-1500 pg/ml.

ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) - SED612Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human 3-hydroxyacyl-CoA dehydratase 1(PTPLA) ELISA kit - CSB-EL019018HU from Cusabio Category ELISA Kit Sensitivity 5.86pg/ml Range 23.44 pg/ml-1500 pg/ml

Human PTPLA ELISA Kit - abx152893 from Abbexa Category ELISA Kit Sensitivity 0.25 ng/ml Range 0.781 ng/ml - 50 ng/ml

Protein Tyrosine Phosphatase Like Protein A (PTPLA), Human, ELISA Kit - DL-PTPLA-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human PTPLA ELISA Kit - abx573622 from Abbexa Category ELISA Kit Sensitivity 0.25 ng/ml Range 0.781 ng/ml - 50 ng/ml

Human 3-hydroxyacyl-CoA dehydratase 1 (PTPLA) ELISA Kit - EKC32399 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 5.86 pg/ml Range 23.44 pg/ml-1500 pg/ml

Human PTPLA ELISA Kit - E031840 from Biobool Category ELISA Kit Sensitivity Typically less than 0.27ng/mL.

Human HACD1 ELISA Kit - E085196 from Biobool Category ELISA Kit

HACD1 ELISA Kit (Human) (OKCD01257) - OKCD01257 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.27 ng/mL Range 0.781-50 ng/mL

Protein Tyrosine Phosphatase Like Protein A (PTPLA), ELISA Kit - MBS451839 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.25ng/mL Range 0.78-50ng/mL

HACD1 ELISA Kit (Human) (OKCA02074) - OKCA02074 from Aviva Systems Biology Category ELISA Kit Sensitivity 5.86 pg/mL Range 23.44 pg/mL-1,500 pg/mL

Search more