| Gene Symbol |
HACD1
|
| Entrez Gene |
9200
|
| Alt Symbol |
CAP, PTPLA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxyacyl-CoA dehydratase 1
|
| Other Description |
cementum attachment protein|cementum-attachment protein|protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
|
| Swissprots |
B0YJ81 Q9UHX2 Q96FW7 Q6JIC5 B0YJ80 Q9HB93
|
| Accessions |
AAG10713 ACA06058 ACA06059 ACA06060 ACA06061 B0YJ81 CAY55982 EAW86210 EAW86211 AF114494 AAF21976 AW022173 AY455942 AAR22554 BC010353 AAH10353 BC027709 HQ447343 ADQ31829 XM_005252641 XP_005252698 XR_428651 NM_014241 NP_055056
|
| Function |
Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
|
| Subcellular Location |
Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
|
| Tissue Specificity |
Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). {ECO:0000269|PubMed:11054553, ECO:0000269|PubMed:22067203}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|
![Western Blot: PTPLA Overexpression Lysate (Adult Normal) [NBL1-14964] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PTPLA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11105_PTPLA%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14964-img0002.jpg)