| Gene Symbol |
TOX3
|
| Entrez Gene |
27324
|
| Alt Symbol |
CAGF9, TNRC9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TOX high mobility group box family member 3
|
| Other Description |
CAG trinucleotide repeat-containing gene F9 protein|trinucleotide repeat containing 9|trinucleotide repeat-containing gene 9 protein
|
| Swissprots |
B4DRD0 B5MCW4 O15405
|
| Accessions |
EAW82787 O15405 AK025084 AK027006 AK095095 AK299202 BAG61242 BC167799 AAI67799 BE501808 U80736 AAB91435 XM_005255892 XP_005255949 XM_005255893 XP_005255950 XM_011523002 XP_011521304 NM_001080430 NP_001073899 NM_001146188 NP_001139660
|
| Function |
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. {ECO:0000269|PubMed:21172805}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe. {ECO:0000269|PubMed:21172805}.
|
![Western Blot: TOX3 Overexpression Lysate (Adult Normal) [NBP2-08493] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TOX3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9456_TOX3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08493-img0001.jpg)