Gene Symbol | TOX3 |
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Entrez Gene | 27324 |
Alt Symbol | CAGF9, TNRC9 |
Species | Human |
Gene Type | protein-coding |
Description | TOX high mobility group box family member 3 |
Other Description | CAG trinucleotide repeat-containing gene F9 protein|trinucleotide repeat containing 9|trinucleotide repeat-containing gene 9 protein |
Swissprots | B4DRD0 B5MCW4 O15405 |
Accessions | EAW82787 O15405 AK025084 AK027006 AK095095 AK299202 BAG61242 BC167799 AAI67799 BE501808 U80736 AAB91435 XM_005255892 XP_005255949 XM_005255893 XP_005255950 XM_011523002 XP_011521304 NM_001080430 NP_001073899 NM_001146188 NP_001139660 |
Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. {ECO:0000269|PubMed:21172805}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe. {ECO:0000269|PubMed:21172805}. |
TOX3 CRISPR/Cas9 KO Plasmid (h) - sc-411992 from Santa Cruz Biotechnology
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TOX3 HDR Plasmid (h) - sc-411992-HDR from Santa Cruz Biotechnology
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TOX3 Double Nickase Plasmid (h) - sc-411992-NIC from Santa Cruz Biotechnology
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TOX3 Double Nickase Plasmid (h2) - sc-411992-NIC-2 from Santa Cruz Biotechnology
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TOX3 CRISPR Activation Plasmid (h) - sc-411992-ACT from Santa Cruz Biotechnology
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TOX3 CRISPR Activation Plasmid (h2) - sc-411992-ACT-2 from Santa Cruz Biotechnology
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TOX3 Lentiviral Activation Particles (h) - sc-411992-LAC from Santa Cruz Biotechnology
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TOX3 Lentiviral Activation Particles (h2) - sc-411992-LAC-2 from Santa Cruz Biotechnology
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TOX3 siRNA (h) - sc-92997 from Santa Cruz Biotechnology
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TOX3 shRNA Plasmid (h) - sc-92997-SH from Santa Cruz Biotechnology
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TOX3 shRNA (h) Lentiviral Particles - sc-92997-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU053691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21840 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21840 from Sigma-Aldrich
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TOX3 siRNA (Human) - CRH9077 from Cohesion Biosciences
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TOX3 - MBS8209497 from MyBioSource
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shRNA set against Human Tox3 (NM_001080430.2) - SHH433032 from Creative biogene
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TOX3 shRNA Plasmid (Human) - CHH9077 from Cohesion Biosciences
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TOX3 miRNA 3'UTR clone - MiUTR3H-11861 from Creative biogene
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TOX3 miRNA 3'UTR clone - MiUTR3H-11862 from Creative biogene
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