| Gene Symbol |
Cd8a
|
| Entrez Gene |
12525
|
| Alt Symbol |
BB154331, Ly-2, Ly-35, Ly-B, Lyt-2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
CD8 antigen, alpha chain
|
| Other Description |
Lyt-2.1 lymphocyte differentiation antigen (AA at 100)|T-cell surface glycoprotein CD8 alpha chain|T-cell surface glycoprotein Lyt-2
|
| Swissprots |
P01731
|
| Accessions |
AAA39474 AAA39475 AAA39665 CAA68352 EDK98938 EDK98939 P01731 AJ131778 AK017889 AK037429 AK037467 BAC29812 AK088128 BAC40163 AK088214 BAC40215 AK088414 BAC40342 AK088447 AK137937 BAE23516 BC030679 AAH30679 M12052 AAA39478 M12825 AAA39476 M16981 AAA39477 U34881 AAA92533 XM_006505464 XP_006505527 XM_006505465 XP_006505528 NM_001081110 NP_001074579 NM_009857 NP_033987
|
| Function |
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation
|