Gene Symbol | Cd8a |
---|---|
Entrez Gene | 12525 |
Alt Symbol | BB154331, Ly-2, Ly-35, Ly-B, Lyt-2 |
Species | Mouse |
Gene Type | protein-coding |
Description | CD8 antigen, alpha chain |
Other Description | Lyt-2.1 lymphocyte differentiation antigen (AA at 100)|T-cell surface glycoprotein CD8 alpha chain|T-cell surface glycoprotein Lyt-2 |
Swissprots | P01731 |
Accessions | AAA39474 AAA39475 AAA39665 CAA68352 EDK98938 EDK98939 P01731 AJ131778 AK017889 AK037429 AK037467 BAC29812 AK088128 BAC40163 AK088214 BAC40215 AK088414 BAC40342 AK088447 AK137937 BAE23516 BC030679 AAH30679 M12052 AAA39478 M12825 AAA39476 M16981 AAA39477 U34881 AAA92533 XM_006505464 XP_006505527 XM_006505465 XP_006505528 NM_001081110 NP_001074579 NM_009857 NP_033987 |
Function | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation |
CD8-α CRISPR/Cas9 KO Plasmid (m) - sc-419576 from Santa Cruz Biotechnology
|
||||||||
CD8-α HDR Plasmid (m) - sc-419576-HDR from Santa Cruz Biotechnology
|
||||||||
CD8-α Double Nickase Plasmid (m) - sc-419576-NIC from Santa Cruz Biotechnology
|
||||||||
CD8-α Double Nickase Plasmid (m2) - sc-419576-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CD8-α CRISPR Activation Plasmid (m) - sc-419576-ACT from Santa Cruz Biotechnology
|
||||||||
CD8-α CRISPR Activation Plasmid (m2) - sc-419576-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CD8-α Lentiviral Activation Particles (m) - sc-419576-LAC from Santa Cruz Biotechnology
|
||||||||
CD8-α Lentiviral Activation Particles (m2) - sc-419576-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CD8-α siRNA (m) - sc-43677 from Santa Cruz Biotechnology
|
||||||||
CD8-α shRNA Plasmid (m) - sc-43677-SH from Santa Cruz Biotechnology
|
||||||||
CD8-α shRNA (m) Lentiviral Particles - sc-43677-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN28392 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28392 from Sigma-Aldrich
|
||||||||
CD8A siRNA (Mouse) - CRM0614 from Cohesion Biosciences
|
||||||||
CD8A - MBS829486 from MyBioSource
|
||||||||
shRNA set against Mouse CD8A (NM_001081110.2) - SHH259453 from Creative biogene
|
||||||||
shRNA set against Mouse Cd8a(NM_001081110.2) - SHG159625 from Creative biogene
|
||||||||
CD8-α CRISPR/Cas9 KO Plasmid (m2) - sc-419576-KO-2 from Santa Cruz Biotechnology
|
||||||||
CD8-α HDR Plasmid (m2) - sc-419576-HDR-2 from Santa Cruz Biotechnology
|
||||||||
Mouse CD8A siRNA - orb280090 from Biorbyt
|
||||||||
CD8A shRNA Plasmid (Mouse) - CHM0614 from Cohesion Biosciences
|
||||||||
CD8A miRNA 3'UTR clone - MiUTR1M-02803 from Creative biogene
|