| Gene Symbol |
USP18
|
| Entrez Gene |
11274
|
| Alt Symbol |
ISG43, UBP43
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 18
|
| Other Description |
43 kDa ISG15-specific protease|ISG15-specific-processing protease|hUBP43|ubiquitin specific protease 18|ubl carboxyl-terminal hydrolase 18|ubl thioesterase 18|ubl thiolesterase 18
|
| Swissprots |
Q53Y90 Q6IAD9 Q9NY71 Q9UMW8
|
| Accessions |
EAW57790 EAW57791 Q9UMW8 AF176642 AAD49967 AI222587 AJ243526 CAB76398 AK313385 BAG36183 AL136690 CAB66625 AM393395 CAL38273 BC014896 AAH14896 BI752849 BT006835 AAP35481 BU584005 CR457216 CAG33497 CT841507 CAJ86437 CU013072 CAK54503 CU013360 CAK54802 XM_006724074 XP_006724137 NM_017414 NP_059110
|
| Function |
Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.
|
| Subcellular Location |
Isoform 1: Cytoplasm.
|