Gene Symbol | USP18 |
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Entrez Gene | 11274 |
Alt Symbol | ISG43, UBP43 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 18 |
Other Description | 43 kDa ISG15-specific protease|ISG15-specific-processing protease|hUBP43|ubiquitin specific protease 18|ubl carboxyl-terminal hydrolase 18|ubl thioesterase 18|ubl thiolesterase 18 |
Swissprots | Q53Y90 Q6IAD9 Q9NY71 Q9UMW8 |
Accessions | EAW57790 EAW57791 Q9UMW8 AF176642 AAD49967 AI222587 AJ243526 CAB76398 AK313385 BAG36183 AL136690 CAB66625 AM393395 CAL38273 BC014896 AAH14896 BI752849 BT006835 AAP35481 BU584005 CR457216 CAG33497 CT841507 CAJ86437 CU013072 CAK54503 CU013360 CAK54802 XM_006724074 XP_006724137 NM_017414 NP_059110 |
Function | Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. |
Subcellular Location | Isoform 1: Cytoplasm. |
USP18 CRISPR/Cas9 KO Plasmid (h) - sc-402259 from Santa Cruz Biotechnology
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USP18 HDR Plasmid (h) - sc-402259-HDR from Santa Cruz Biotechnology
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USP18 Double Nickase Plasmid (h) - sc-402259-NIC from Santa Cruz Biotechnology
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USP18 Double Nickase Plasmid (h2) - sc-402259-NIC-2 from Santa Cruz Biotechnology
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USP18 CRISPR Activation Plasmid (h) - sc-402259-ACT from Santa Cruz Biotechnology
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USP18 CRISPR Activation Plasmid (h2) - sc-402259-ACT-2 from Santa Cruz Biotechnology
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USP18 Lentiviral Activation Particles (h) - sc-402259-LAC from Santa Cruz Biotechnology
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USP18 Lentiviral Activation Particles (h2) - sc-402259-LAC-2 from Santa Cruz Biotechnology
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USP18 siRNA (h) - sc-60865 from Santa Cruz Biotechnology
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USP18 shRNA Plasmid (h) - sc-60865-SH from Santa Cruz Biotechnology
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USP18 shRNA (h) Lentiviral Particles - sc-60865-V from Santa Cruz Biotechnology
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USP18 RNAi - H00011274-R01 from Novus Biologicals
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MISSION® esiRNA - EHU105111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22566 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22566 from Sigma-Aldrich
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USP18 siRNA (Human) - CRH7729 from Cohesion Biosciences
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USP18 - MBS8204748 from MyBioSource
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shRNA set against Human USP18 (NM_017414.3) - SHH441317 from Creative biogene
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shRNA set against Human USP18(NM_017414.3) - SHL117484 from Creative biogene
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USP18 shRNA Plasmid (Human) - CHH7729 from Cohesion Biosciences
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USP18 miRNA 3'UTR clone - MiUTR1H-11052 from Creative biogene
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