Gene Symbol | SFRP2 |
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Entrez Gene | 6423 |
Alt Symbol | FRP-2, SARP1, SDF-5 |
Species | Human |
Gene Type | protein-coding |
Description | secreted frizzled-related protein 2 |
Other Description | SARP-1|sFRP-2|secreted apoptosis related protein 1|secreted apoptosis-related protein 1 |
Swissprots | Q9HAP5 Q96HF1 O14778 B3KQR2 |
Accessions | CAZ76869 EAX04949 Q96HF1 AA449032 AF017986 AAB70792 AF311912 AAG24923 AK075372 BAG52124 AK093922 BAG52787 AY359001 AAQ89360 BC008666 AAH08666 BM906663 BM924815 BQ130455 CN431016 NM_003013 NP_003004 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. {ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}. |
Top Pathways | Wnt signaling pathway |
FRP-2 CRISPR/Cas9 KO Plasmid (h) - sc-402000 from Santa Cruz Biotechnology
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FRP-2 HDR Plasmid (h) - sc-402000-HDR from Santa Cruz Biotechnology
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FRP-2 Double Nickase Plasmid (h) - sc-402000-NIC from Santa Cruz Biotechnology
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FRP-2 Double Nickase Plasmid (h2) - sc-402000-NIC-2 from Santa Cruz Biotechnology
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FRP-2 CRISPR Activation Plasmid (h) - sc-402000-ACT from Santa Cruz Biotechnology
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FRP-2 CRISPR Activation Plasmid (h2) - sc-402000-ACT-2 from Santa Cruz Biotechnology
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FRP-2 Lentiviral Activation Particles (h) - sc-402000-LAC from Santa Cruz Biotechnology
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FRP-2 Lentiviral Activation Particles (h2) - sc-402000-LAC-2 from Santa Cruz Biotechnology
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FRP-2 siRNA (h) - sc-40000 from Santa Cruz Biotechnology
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FRP-2 shRNA Plasmid (h) - sc-40000-SH from Santa Cruz Biotechnology
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FRP-2 shRNA (h) Lentiviral Particles - sc-40000-V from Santa Cruz Biotechnology
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sFRP-2 RNAi - H00006423-R02 from Novus Biologicals
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MISSION® esiRNA - EHU038301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1548 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1548 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07125 from Sigma-Aldrich
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SFRP2 siRNA (Human) - CRH4338 from Cohesion Biosciences
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SFRP2 - MBS8217062 from MyBioSource
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SFRP2 shRNA Plasmid (Human) - CHH4338 from Cohesion Biosciences
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