| Gene Symbol |
SMAD5
|
| Entrez Gene |
4090
|
| Alt Symbol |
DWFC, JV5-1, MADH5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 5
|
| Other Description |
MAD, mothers against decapentaplegic homolog 5|SMA- and MAD-related protein 5|SMAD, mothers against DPP homolog 5|mothers against decapentaplegic homolog 5|mothers against decapentaplegic, drosophila, homolog of, 5
|
| Swissprots |
Q15798 Q99717 Q9UQA1 O14688
|
| Accessions |
AAB82655 AAB92396 EAW62194 EAW62195 EAW62196 Q99717 AF009678 AAB72180 AF009745 AF010601 AAB66353 AF071106 AAD20799 AF071107 AAD20800 AF071108 AAD20801 AF071109 AAD20802 AF071110 AAD20803 AK001036 AK055211 AK311231 AK313397 BAG36195 BC009682 AAH09682 BK001394 BX510058 BX646699 BX648328 CR457424 CAG33705 CR749366 CAH18219 CR749473 CAH18303 HQ448272 ADQ32752 U59913 AAC50791 U73825 AAB95090 NM_001001419 NP_001001419 NM_001001420 NP_001001420 NM_005903 NP_005894
|
| Function |
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|