Gene Symbol | SMAD5 |
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Entrez Gene | 4090 |
Alt Symbol | DWFC, JV5-1, MADH5 |
Species | Human |
Gene Type | protein-coding |
Description | SMAD family member 5 |
Other Description | MAD, mothers against decapentaplegic homolog 5|SMA- and MAD-related protein 5|SMAD, mothers against DPP homolog 5|mothers against decapentaplegic homolog 5|mothers against decapentaplegic, drosophila, homolog of, 5 |
Swissprots | Q15798 Q99717 Q9UQA1 O14688 |
Accessions | AAB82655 AAB92396 EAW62194 EAW62195 EAW62196 Q99717 AF009678 AAB72180 AF009745 AF010601 AAB66353 AF071106 AAD20799 AF071107 AAD20800 AF071108 AAD20801 AF071109 AAD20802 AF071110 AAD20803 AK001036 AK055211 AK311231 AK313397 BAG36195 BC009682 AAH09682 BK001394 BX510058 BX646699 BX648328 CR457424 CAG33705 CR749366 CAH18219 CR749473 CAH18303 HQ448272 ADQ32752 U59913 AAC50791 U73825 AAB95090 NM_001001419 NP_001001419 NM_001001420 NP_001001420 NM_005903 NP_005894 |
Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). |
Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. |
Tissue Specificity | Ubiquitous. |
Top Pathways | TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Smad5 CRISPR/Cas9 KO Plasmid (h) - sc-400443 from Santa Cruz Biotechnology
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Smad5 HDR Plasmid (h) - sc-400443-HDR from Santa Cruz Biotechnology
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Smad5 Double Nickase Plasmid (h) - sc-400443-NIC from Santa Cruz Biotechnology
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Smad5 Double Nickase Plasmid (h2) - sc-400443-NIC-2 from Santa Cruz Biotechnology
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Smad5 CRISPR Activation Plasmid (h) - sc-400443-ACT from Santa Cruz Biotechnology
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Smad5 CRISPR Activation Plasmid (h2) - sc-400443-ACT-2 from Santa Cruz Biotechnology
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Smad5 Lentiviral Activation Particles (h) - sc-400443-LAC from Santa Cruz Biotechnology
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Smad5 Lentiviral Activation Particles (h2) - sc-400443-LAC-2 from Santa Cruz Biotechnology
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Smad5 siRNA (h) - sc-38378 from Santa Cruz Biotechnology
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Smad5 shRNA Plasmid (h) - sc-38378-SH from Santa Cruz Biotechnology
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Smad5 shRNA (h) Lentiviral Particles - sc-38378-V from Santa Cruz Biotechnology
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Smad5 RNAi - H00004090-R02 from Novus Biologicals
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Smad5 RNAi - H00004090-R03 from Novus Biologicals
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MISSION® esiRNA - EHU089731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19752 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19752 from Sigma-Aldrich
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SMAD5 siRNA (Human) - CRH2773 from Cohesion Biosciences
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Smad5 RNAi - H00004090-R01 from Novus Biologicals
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SMAD5 - MBS8206868 from MyBioSource
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shRNA set against Human SMAD5 (NM_005903.5) - SHH412996 from Creative biogene
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shRNA set against Human SMAD5(NM_005903.5) - SHL014894 from Creative biogene
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shRNA set against Human SMAD5(NM_001001419.1) - SHL015228 from Creative biogene
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shRNA set against Human SMAD5(NM_005903.5) - SHL015246 from Creative biogene
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Human SMAD5 siRNA - orb263275 from Biorbyt
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SMAD5 shRNA Plasmid (Human) - CHH2773 from Cohesion Biosciences
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