| Gene Symbol |
PRKX
|
| Entrez Gene |
5613
|
| Alt Symbol |
PKX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, X-linked
|
| Other Description |
cAMP-dependent protein kinase catalytic subunit PRKX|protein kinase PKX1|protein kinase X|protein kinase X-linked|serine/threonine-protein kinase PRKX
|
| Swissprots |
P51817
|
| Accessions |
CBX55118 EAW98726 EAW98727 EAW98728 P51817 BC041073 AAH41073 BE675757 DN996851 DN997580 EU832357 ACE87614 EU832442 ACE86927 X85545 CAA59733 XM_005274560 XP_005274617 XM_005274561 XP_005274618 XM_011545544 XP_011543846 NM_005044 NP_005035
|
| Function |
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
|
| Tissue Specificity |
Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269|PubMed:15879576, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:7633447, ECO:0000269|PubMed:9860982}.
|
| Top Pathways |
Adrenergic signaling in cardiomyocytes, Ovarian steroidogenesis, Wnt signaling pathway, Proteoglycans in cancer, Estrogen signaling pathway
|