PRKX

Gene Symbol	PRKX
Entrez Gene	5613
Alt Symbol	PKX1
Species	Human
Gene Type	protein-coding
Description	protein kinase, X-linked
Other Description	cAMP-dependent protein kinase catalytic subunit PRKX|protein kinase PKX1|protein kinase X|protein kinase X-linked|serine/threonine-protein kinase PRKX
Swissprots	P51817
Accessions	CBX55118 EAW98726 EAW98727 EAW98728 P51817 BC041073 AAH41073 BE675757 DN996851 DN997580 EU832357 ACE87614 EU832442 ACE86927 X85545 CAA59733 XM_005274560 XP_005274617 XM_005274561 XP_005274618 XM_011545544 XP_011543846 NM_005044 NP_005035
Function	Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.
Subcellular Location	Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Tissue Specificity	Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269|PubMed:15879576, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:7633447, ECO:0000269|PubMed:9860982}.
Top Pathways	Adrenergic signaling in cardiomyocytes, Ovarian steroidogenesis, Wnt signaling pathway, Proteoglycans in cancer, Estrogen signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PRKX full length protein - ab125604 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PRKX full length protein - ab152637 from Abcam Category Protein Source Wheat germ Species Human

Human PRKX protein fragment - ab114807 from Abcam Category Protein Source Wheat germ Species Human

PRKX Antibody Blocking Peptide - LS-E2956 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKX Antibody Blocking Peptide - LS-E20585 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKX Antibody Blocking Peptide - LS-E9383 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PRKX Protein - H00005613-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PRKX Protein - H00005613-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRKX Peptide - P2923 from Novus Biologicals Category Peptide Species Human

PRKX-Antibody-C-term-Blocking-Peptide - BP7940a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKX Blocking Peptide - 33R-5894 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKX Blocking Peptide - abx063147 from Abbexa Category Peptide Species Human, Mouse, Rat

PRKX / PKX1 - H00005613-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PRKX / PKX1 - H00005613-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PRKX / PKX1 - H00005613-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKX / PKX1 - H00005613-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKX / PKX1 - P5627 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PRKX fusion protein - ag10083 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PRKX - PRKX-30107TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PRKX, GST-tagged - PRKX-1963H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein Kinase, X-Linked, GST-tagged - PRKX-1090H from Creative Biomart Category Protein Species Human

Recombinant Protein Kinase, X-Linked (PRKX) - RPH312Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

PRKX Protein, active, 250 µg - 14-677M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-677) and in bulk (cat#14-677-K) Source expressed by baculovirus in Sf21 cells

PRKX Protein, active, 10 µg - 14-677 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

PRKX Blocking Peptide - CBP1953 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

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