JADE1
| Gene Symbol | JADE1 |
|---|---|
| Entrez Gene | 79960 |
| Alt Symbol | PHF17 |
| Species | Human |
| Gene Type | protein-coding |
| Description | jade family PHD finger 1 |
| Other Description | PHD finger protein 17|PHD protein Jade-1|gene for apoptosis and differentiation in epithelia|jade family PHD finger protein 1|protein Jade-1 |
| Swissprots | Q8NC41 D3DNY1 Q96SQ1 Q96JL8 Q4W5D5 Q9H692 Q6IE81 D3DNY0 Q6ZSL7 |
| Accessions | AAY40997 EAX05170 EAX05171 EAX05172 EAX05173 EAX05174 EAX05175 EAX05176 Q6IE81 AB058710 BAB47436 AF520952 AAM95612 AK026132 BAB15371 AK027620 BAB55239 AK074986 BAC11335 AK127326 BAC86931 AK304235 BAG65104 AK304815 BAG65565 BC032376 AAH32376 BI463062 BN000287 CAE30500 BX107708 DA478923 DA714593 DB085413 DB293142 DB451567 DC308420 DC308588 DQ891572 ABM82498 DQ894766 ABM85692 XM_005263232 XP_005263289 XM_011532260 XP_011530562 NM_001287437 NP_001274366 NM_001287439 NP_001274368 NM_001287440 NP_001274369 NM_001287441 NP_001274370 NM_001287442 NP_001274371 NM_001287443 NP_001274372 NM_024900 NP_079176 NM_199320 NP_955352 |
| Function | Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:16046545}. |
Jade-1 CRISPR/Cas9 KO Plasmid (h) - sc-410620 from Santa Cruz Biotechnology
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Jade-1 HDR Plasmid (h) - sc-410620-HDR from Santa Cruz Biotechnology
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Jade-1 Double Nickase Plasmid (h) - sc-410620-NIC from Santa Cruz Biotechnology
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Jade-1 Double Nickase Plasmid (h2) - sc-410620-NIC-2 from Santa Cruz Biotechnology
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Jade-1 CRISPR Activation Plasmid (h) - sc-410620-ACT from Santa Cruz Biotechnology
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Jade-1 CRISPR Activation Plasmid (h2) - sc-410620-ACT-2 from Santa Cruz Biotechnology
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Jade-1 Lentiviral Activation Particles (h) - sc-410620-LAC from Santa Cruz Biotechnology
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Jade-1 Lentiviral Activation Particles (h2) - sc-410620-LAC-2 from Santa Cruz Biotechnology
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Jade-1 siRNA (h) - sc-88893 from Santa Cruz Biotechnology
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Jade-1 shRNA Plasmid (h) - sc-88893-SH from Santa Cruz Biotechnology
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Jade-1 shRNA (h) Lentiviral Particles - sc-88893-V from Santa Cruz Biotechnology
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Jade-1/PHF17 RNAi - H00079960-R01 from Novus Biologicals
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MISSION® esiRNA - EHU155101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16722 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16722 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11450 from Sigma-Aldrich
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JADE1 siRNA (Human) - CRJ2694 from Cohesion Biosciences
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Jade-1/PHF17 RNAi - H00079960-R02 from Novus Biologicals
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JADE1, siRNA - MBS8211272 from MyBioSource
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shRNA set against Human PHF17 (NM_199320.2) - SHH374692 from Creative biogene
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shRNA set against Human PHF17(NM_024900.3) - SHR111048 from Creative biogene
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shRNA set against Human PHF17(NM_199320.2) - SHR111066 from Creative biogene
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JADE1 shRNA Plasmid (Human) - CHJ2694 from Cohesion Biosciences
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PHF17 miRNA 3'UTR clone - MiUTR1H-07852 from Creative biogene
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PHF17 miRNA 3'UTR clone - MiUTR1H-07853 from Creative biogene
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