| Gene Symbol |
STIL
|
| Entrez Gene |
6491
|
| Alt Symbol |
MCPH7, SIL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SCL/TAL1 interrupting locus
|
| Other Description |
SCL-interrupting locus protein|TAL-1-interrupting locus protein
|
| Swissprots |
Q5T0C5 Q68CN9 Q15468
|
| Accessions |
AAK51418 CAI19730 CAI19731 CAI19732 CAI19733 EAX06872 EAX06873 EAX06874 Q15468 AA897748 AK098445 AK128406 AK307519 BC053615 AAH53615 BC126223 AAI26224 BC136432 BC144089 AAI44090 CR749851 CAH18699 DA754072 DB062060 DB062487 HQ258539 ADR83293 M74558 AAA60550 XM_006710834 XP_006710897 XM_011541991 XP_011540293 XM_011541992 XP_011540294 XM_011541993 XP_011540295 XM_011541994 XP_011540296 XM_011541995 XP_011540297 XM_011541996 XP_011540298 XM_011541997 XP_011540299 XM_011541998 XP_011540300 XM_011541999 XP_011540301 XM_011542000 XP_011540302 XM_011542001 XP_011540303 XR_946746 NM_001048166 NP_001041631 NM_001282936 NP_001269865 NM_001282937 NP_001269866 NM_001282938 NP_001269867 NM_001282939 NP_001269868 NM_003035 NP_003026
|
| Function |
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:9372240}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. {ECO:0000269|PubMed:15107824, ECO:0000269|PubMed:1922059}.
|