| Gene Symbol | STIL |
|---|---|
| Entrez Gene | 6491 |
| Alt Symbol | MCPH7, SIL |
| Species | Human |
| Gene Type | protein-coding |
| Description | SCL/TAL1 interrupting locus |
| Other Description | SCL-interrupting locus protein|TAL-1-interrupting locus protein |
| Swissprots | Q5T0C5 Q68CN9 Q15468 |
| Accessions | AAK51418 CAI19730 CAI19731 CAI19732 CAI19733 EAX06872 EAX06873 EAX06874 Q15468 AA897748 AK098445 AK128406 AK307519 BC053615 AAH53615 BC126223 AAI26224 BC136432 BC144089 AAI44090 CR749851 CAH18699 DA754072 DB062060 DB062487 HQ258539 ADR83293 M74558 AAA60550 XM_006710834 XP_006710897 XM_011541991 XP_011540293 XM_011541992 XP_011540294 XM_011541993 XP_011540295 XM_011541994 XP_011540296 XM_011541995 XP_011540297 XM_011541996 XP_011540298 XM_011541997 XP_011540299 XM_011541998 XP_011540300 XM_011541999 XP_011540301 XM_011542000 XP_011540302 XM_011542001 XP_011540303 XR_946746 NM_001048166 NP_001041631 NM_001282936 NP_001269865 NM_001282937 NP_001269866 NM_001282938 NP_001269867 NM_001282939 NP_001269868 NM_003035 NP_003026 |
| Function | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:9372240}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. |
| Tissue Specificity | Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. {ECO:0000269|PubMed:15107824, ECO:0000269|PubMed:1922059}. |
Sil CRISPR/Cas9 KO Plasmid (h) - sc-409193 from Santa Cruz Biotechnology
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Sil HDR Plasmid (h) - sc-409193-HDR from Santa Cruz Biotechnology
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Sil Double Nickase Plasmid (h) - sc-409193-NIC from Santa Cruz Biotechnology
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Sil Double Nickase Plasmid (h2) - sc-409193-NIC-2 from Santa Cruz Biotechnology
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Sil CRISPR Activation Plasmid (h) - sc-409193-ACT from Santa Cruz Biotechnology
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Sil CRISPR Activation Plasmid (h2) - sc-409193-ACT-2 from Santa Cruz Biotechnology
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Sil Lentiviral Activation Particles (h) - sc-409193-LAC from Santa Cruz Biotechnology
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Sil Lentiviral Activation Particles (h2) - sc-409193-LAC-2 from Santa Cruz Biotechnology
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Sil siRNA (h) - sc-44775 from Santa Cruz Biotechnology
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Sil shRNA Plasmid (h) - sc-44775-SH from Santa Cruz Biotechnology
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Sil shRNA (h) Lentiviral Particles - sc-44775-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU069261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20724 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13076 from Sigma-Aldrich
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STIL siRNA (Human) - CRH4387 from Cohesion Biosciences
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STIL - MBS8238963 from MyBioSource
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shRNA set against Human STIL (NM_003035.2) - SHH419628 from Creative biogene
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shRNA set against Human STIL(NM_001048166.1) - SHL033558 from Creative biogene
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shRNA set against Human STIL(NM_003035.2) - SHL033808 from Creative biogene
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Human STIL siRNA - orb264889 from Biorbyt
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STIL shRNA Plasmid (Human) - CHH4387 from Cohesion Biosciences
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STIL miRNA 3'UTR clone - MiUTR1H-09997 from Creative biogene
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STIL miRNA 3'UTR clone - MiUTR1H-09998 from Creative biogene
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