| Gene Symbol |
SASS6
|
| Entrez Gene |
163786
|
| Alt Symbol |
SAS-6, SAS6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindle assembly 6 homolog (C. elegans)
|
| Other Description |
hsSAS-6|spindle assembly abnormal protein 6 homolog
|
| Swissprots |
D3DT55 Q8N3K0 Q6UVJ0
|
| Accessions |
EAW72974 EAW72975 Q6UVJ0 AK025750 AK302513 BAG63789 AK307824 AL834265 CAD38940 AY359522 AAQ57128 BC054889 BC101026 AAI01027 BX113339 BX641109 BX648406 DC400869 NM_001304829 NP_001291758 NM_194292 NP_919268
|
| Function |
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. {ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis. {ECO:0000250}.
|