WIPI1

Gene Symbol	WIPI1
Entrez Gene	55062
Alt Symbol	ATG18, ATG18A, WIPI49
Species	Human
Gene Type	protein-coding
Description	WD repeat domain, phosphoinositide interacting 1
Other Description	WD repeat domain phosphoinositide-interacting protein 1|WD40 repeat protein Interacting with phosphoInositides of 49kDa|WD40 repeat protein interacting with phosphoinositides of 49 kDa|WIPI 49 kDa|WIPI-1 alpha|atg18 protein homolog
Swissprots	Q9NWF8 Q8IXM5 Q5MNZ9
Accessions	EAW89057 EAW89058 EAW89059 Q5MNZ9 AK000917 BAA91423 AK301830 BAG63275 AY691424 AAV80760 BC039867 AAH39867 DC380076 JF432423 ADZ15640 XM_005257497 XP_005257554 XR_934496 NM_017983 NP_060453
Function	Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497}.
Subcellular Location	Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
Tissue Specificity	Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues. {ECO:0000269|PubMed:15602573}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WIPI1 full length protein - ab162948 from Abcam Category Protein Source Wheat germ Species Human

Human WIPI1 protein fragment - ab162949 from Abcam Category Protein Source Wheat germ Species Human

ATG18 / WIPI1 Antibody Blocking Peptide - LS-E5117 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG18 / WIPI1 Antibody Blocking Peptide - LS-E31337 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ATG18 / WIPI1 Antibody Blocking Peptide - LS-E20813 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG18 / WIPI1 Antibody Blocking Peptide - LS-E20812 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WIPI1 Protein - H00055062-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WIPI1 Partial Recombinant Protein - H00055062-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

WIPI1-Antibody-Center-Blocking-Peptide - BP17541c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WIPI1 Blocking Peptide - 33R-5144 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WIPI1 Blocking Peptide - 33R-1237 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WIPI-1 - H00055062-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WIPI-1 - H00055062-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WIPI-1 - H00055062-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WIPI-1 - H00055062-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WIPI-1 (C-term) Control Peptide - AP55473CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

WIPI1 Peptide - 7041P from ProSci Category Peptide Species Human

WIPI1 fusion protein - Ag18461 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human WIPI1, GST-tagged - WIPI1-3733H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human WD repeat domain phosphoinositide-interacting protein 1(WIPI1) - CSB-YP705810HU CSB-EP705810HU CSB-BP705810HU CSB-MP705810HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WIPI1 Protein - abx164413 from Abbexa Category Protein Species Human, Mouse, Rat

WD repeat domain phosphoinositide-interacting protein 1 (WIPI1) , Recombinant Protein - MBS1305997 from MyBioSource Category Protein Prices $1,985.00, $1,985.00, $2,450.00, $2,450.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WIPI1 Protein - NBP1-88878PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

WIPI1-Blocking-Peptide-N-term - BP20115a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WIPI1 Peptide, Human - M34GP17500H from Creative Peptides Category Peptide Source Synthetic. Species Human

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