WIPI1

Gene Symbol	WIPI1
Entrez Gene	55062
Alt Symbol	ATG18, ATG18A, WIPI49
Species	Human
Gene Type	protein-coding
Description	WD repeat domain, phosphoinositide interacting 1
Other Description	WD repeat domain phosphoinositide-interacting protein 1|WD40 repeat protein Interacting with phosphoInositides of 49kDa|WD40 repeat protein interacting with phosphoinositides of 49 kDa|WIPI 49 kDa|WIPI-1 alpha|atg18 protein homolog
Swissprots	Q9NWF8 Q8IXM5 Q5MNZ9
Accessions	EAW89057 EAW89058 EAW89059 Q5MNZ9 AK000917 BAA91423 AK301830 BAG63275 AY691424 AAV80760 BC039867 AAH39867 DC380076 JF432423 ADZ15640 XM_005257497 XP_005257554 XR_934496 NM_017983 NP_060453
Function	Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497}.
Subcellular Location	Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
Tissue Specificity	Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues. {ECO:0000269|PubMed:15602573}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WIPI1 Antibody - 12124 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

WIPI-1 (F-6) - sc-376205 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

WIPI-1 (H-95) - sc-292635 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

WIPI-1 (K-20) - sc-83064 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WIPI-1 (D-19) - sc-83063 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WIPI-1 (38-W) - sc-100901 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-WIPI1 antibody - ab139722 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WIPI1 antibody - ab183766 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WIPI1 antibody - ab57404 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-WIPI1 antibody - ab99199 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WIPI1 antibody - ab98267 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WIPI1 antibody [EPR8110] - ab128901 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8110

Anti-WIPI1 antibody - C-terminal - ab189959 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WIPI1 antibody - N-terminal - ab156610 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (C-Terminus) IHC-plus™ - LS-B8869 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, AP) - LS-C242752 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, Biotin) - LS-C242753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, APC) - LS-C242754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, FITC) - LS-C242755 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, PE) - LS-C242760 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232, Azide-free, HRP) - LS-C247255 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa201-232) - LS-C326364 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody (aa348-446, Azide-free) - LS-C329097 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-ATG18 / WIPI1 Antibody (aa35-84) - LS-C111967 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ATG18 / WIPI1 Antibody - LS-C343715 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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