| Gene Symbol |
CD300A
|
| Entrez Gene |
11314
|
| Alt Symbol |
CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD300a molecule
|
| Other Description |
CD300 antigen-like family member A|CD300a antigen|CMRF35-like molecule 8|CMRF35H leukocyte immunoglobulin-like receptor|NK inhibitory receptor|immunoglobulin superfamily member 12|inhibitory receptor protein 60|leukocyte membrane antigen
|
| Swissprots |
A8MW96 Q9HD97 Q9UMT0 Q9P0F3 Q9UBK4 Q9UMS9 Q9UGN4 O95100
|
| Accessions |
AAF89957 CCF77000 CDM22292 EAW89166 EAW89167 EAW89168 Q9UGN4 AF020314 AAD01646 AF161346 AAF28906 AJ010101 CAB52291 AJ010102 CAB52292 AJ010103 CAB52293 AJ224864 CAB55347 AJ238323 CAB66145 AK309631 AK309636 BC020681 BC032352 AAH32352 BF059016 BM923070 XM_005256990 XP_005257047 XM_005256991 XP_005257048 XM_005256992 XP_005257049 XM_006721656 XP_006721719 XM_011524254 XP_011522556 NM_001256841 NP_001243770 NM_007261 NP_009192
|
| Function |
Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:9701027}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. {ECO:0000269|PubMed:10540326, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:9701027}.
|
