Gene Symbol | CD300A |
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Entrez Gene | 11314 |
Alt Symbol | CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60 |
Species | Human |
Gene Type | protein-coding |
Description | CD300a molecule |
Other Description | CD300 antigen-like family member A|CD300a antigen|CMRF35-like molecule 8|CMRF35H leukocyte immunoglobulin-like receptor|NK inhibitory receptor|immunoglobulin superfamily member 12|inhibitory receptor protein 60|leukocyte membrane antigen |
Swissprots | A8MW96 Q9HD97 Q9UMT0 Q9P0F3 Q9UBK4 Q9UMS9 Q9UGN4 O95100 |
Accessions | AAF89957 CCF77000 CDM22292 EAW89166 EAW89167 EAW89168 Q9UGN4 AF020314 AAD01646 AF161346 AAF28906 AJ010101 CAB52291 AJ010102 CAB52292 AJ010103 CAB52293 AJ224864 CAB55347 AJ238323 CAB66145 AK309631 AK309636 BC020681 BC032352 AAH32352 BF059016 BM923070 XM_005256990 XP_005257047 XM_005256991 XP_005257048 XM_005256992 XP_005257049 XM_006721656 XP_006721719 XM_011524254 XP_011522556 NM_001256841 NP_001243770 NM_007261 NP_009192 |
Function | Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:9701027}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. {ECO:0000269|PubMed:10540326, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:9701027}. |
CD300A CRISPR/Cas9 KO Plasmid (h) - sc-416522 from Santa Cruz Biotechnology
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CD300A HDR Plasmid (h) - sc-416522-HDR from Santa Cruz Biotechnology
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CD300A Double Nickase Plasmid (h) - sc-416522-NIC from Santa Cruz Biotechnology
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CD300A Double Nickase Plasmid (h2) - sc-416522-NIC-2 from Santa Cruz Biotechnology
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CD300A CRISPR Activation Plasmid (h) - sc-416522-ACT from Santa Cruz Biotechnology
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CD300A CRISPR Activation Plasmid (h2) - sc-416522-ACT-2 from Santa Cruz Biotechnology
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CD300A Lentiviral Activation Particles (h) - sc-416522-LAC from Santa Cruz Biotechnology
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CD300A Lentiviral Activation Particles (h2) - sc-416522-LAC-2 from Santa Cruz Biotechnology
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CD300A siRNA (h) - sc-93624 from Santa Cruz Biotechnology
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CD300A shRNA Plasmid (h) - sc-93624-SH from Santa Cruz Biotechnology
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CD300A shRNA (h) Lentiviral Particles - sc-93624-V from Santa Cruz Biotechnology
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CD300a/LMIR1 RNAi - H00011314-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5712 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5712 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05833 from Sigma-Aldrich
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CD300A siRNA (Human) - CRH7744 from Cohesion Biosciences
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CD300A - MBS8224227 from MyBioSource
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shRNA set against Human CD300A (NM_007261.3) - SHH258889 from Creative biogene
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Human CD300A siRNA - orb268246 from Biorbyt
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CD300A shRNA Plasmid (Human) - CHH7744 from Cohesion Biosciences
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CD300A miRNA 3'UTR clone - MiUTR3H-08715 from Creative biogene
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