| Gene Symbol | LCP1 |
|---|---|
| Entrez Gene | 3936 |
| Alt Symbol | CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lymphocyte cytosolic protein 1 (L-plastin) |
| Other Description | L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)|LCP-1|Lymphocyte cytosolic protein-1 (plasmin)|bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))|epididymis secretory protein Li 37|plastin 2|plastin-2 |
| Swissprots | P13796 Q5TBN4 B4DUA0 B2R613 |
| Accessions | EAX08757 EAX08758 P13796 AB208984 BAD92221 AK058152 AK093568 AK097174 AK097275 BAG53443 AK129625 AK223305 BAD97025 AK300556 BAG62262 AK309009 AK312393 BAG35310 AY960627 BC007673 AAH07673 BC010271 AAH10271 BC015001 BC053839 BF893502 CR936795 DA820090 DB156931 DQ892935 ABM83861 DQ896184 ABM87183 EU794648 ACJ13702 J02923 AAA63236 M22300 AAB02845 M34426 AAA36184 XM_005266374 XP_005266431 NM_002298 NP_002289 |
| Function | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation. {ECO:0000250}. |
| Tissue Specificity | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. {ECO:0000269|PubMed:3261603}. |