| Gene Symbol | SEPT6 |
|---|---|
| Entrez Gene | 23157 |
| Alt Symbol | SEP2, SEPT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | septin 6 |
| Other Description | septin 2|septin-6 |
| Swissprots | Q96P87 Q14141 Q96GR1 Q96P86 Q96A13 Q5JTK0 Q969W5 |
| Accessions | EAW89851 EAW89852 EAW89853 EAW89854 EAW89855 EAW89856 EAW89857 EAW89858 Q14141 AF397023 AAN76547 AF403058 AAK98547 AF403059 AAK98548 AF403060 AAK98549 AF403061 AAK98550 AF403062 AAK98551 AK026589 AK290977 BAF83666 AK298487 BAG60696 AK299273 BAG61293 AK303116 BAG64222 AK303224 BAG64311 AL833677 AY005981 AAF97496 AY034177 AAK61492 AY679521 AAT80339 BC009291 AAH09291 BC011922 AAH11922 BC036240 AAH36240 BC069231 AAH69231 D50918 BAA09477 DC336432 HQ447923 ADQ32407 XM_005262400 XP_005262457 XM_006724748 XP_006724811 XM_006724750 XP_006724813 XM_011531317 XP_011529619 XM_011531318 XP_011529620 XR_938548 NM_015129 NP_055944 NM_145799 NP_665798 NM_145800 NP_665799 NM_145802 NP_665801 |
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15915442}. |
| Top Pathways | Bacterial invasion of epithelial cells |
Septin 6 CRISPR/Cas9 KO Plasmid (h) - sc-405243 from Santa Cruz Biotechnology
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Septin 6 HDR Plasmid (h) - sc-405243-HDR from Santa Cruz Biotechnology
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Septin 6 Double Nickase Plasmid (h) - sc-405243-NIC from Santa Cruz Biotechnology
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Septin 6 Double Nickase Plasmid (h2) - sc-405243-NIC-2 from Santa Cruz Biotechnology
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Septin 6 CRISPR Activation Plasmid (h) - sc-405243-ACT from Santa Cruz Biotechnology
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Septin 6 CRISPR Activation Plasmid (h2) - sc-405243-ACT-2 from Santa Cruz Biotechnology
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Septin 6 Lentiviral Activation Particles (h) - sc-405243-LAC from Santa Cruz Biotechnology
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Septin 6 Lentiviral Activation Particles (h2) - sc-405243-LAC-2 from Santa Cruz Biotechnology
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Septin 6 siRNA (h) - sc-40938 from Santa Cruz Biotechnology
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Septin 6 shRNA Plasmid (h) - sc-40938-SH from Santa Cruz Biotechnology
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Septin 6 shRNA (h) Lentiviral Particles - sc-40938-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19107 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19107 from Sigma-Aldrich
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SEPT6 siRNA (Human) - CRH8041 from Cohesion Biosciences
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SEPT6 - MBS8234553 from MyBioSource
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shRNA set against Human SEPT6 (NM_015129.5) - SHH404656 from Creative biogene
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shRNA set against Human SEPT6(NM_145799.3) - SHR215362 from Creative biogene
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shRNA set against Human SEPT6(NM_145802.3) - SHR215408 from Creative biogene
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SEPT6 shRNA Plasmid (Human) - CHH8041 from Cohesion Biosciences
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SEPT6 miRNA 3'UTR clone - MiUTR1H-09276 from Creative biogene
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SEPT6 miRNA 3'UTR clone - MiUTR1H-09277 from Creative biogene
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SEPT6 miRNA 3'UTR clone - MiUTR1H-09278 from Creative biogene
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SEPT6 miRNA 3'UTR clone - MiUTR3H-02899 from Creative biogene
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