| Gene Symbol | TAOK3 |
|---|---|
| Entrez Gene | 51347 |
| Alt Symbol | DPK, JIK, MAP3K18 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAO kinase 3 |
| Other Description | CTCL-associated antigen HD-CL-09|JNK/SAPK-inhibitory kinase|STE20-like kinase|cutaneous T-cell lymphoma-associated antigen HD-CL-09|dendritic cell-derived protein kinase|hKFC-A|jun kinase-inhibitory kinase|kinase from chicken homolog A|serine/threonine-protein kinase TAO3|thousand and one amino acid protein 3 |
| Swissprots | Q9NZM9 Q9HC79 Q8IUM4 Q9UHG7 Q658N1 Q9H2K8 |
| Accessions | CBX51415 EAW98124 EAW98125 Q9H2K8 AA744362 AF135158 AAG09131 AF161373 AAF28933 AF179867 AAF14559 AF181985 AAF25817 AF263311 AAG38501 AF328731 AAN09723 AI057643 AK056370 BAG51691 AK289558 BAF82247 AL833460 AL833731 CAH56239 BC002756 AAH02756 BT007185 AAP35849 BX649175 DB066061 DQ890696 ABM81622 DQ893881 ABM84807 XM_005253897 XP_005253954 XM_005253898 XP_005253955 XM_006719445 XP_006719508 XM_006719446 XP_006719509 XM_011538437 XP_011536739 XM_011538438 XP_011536740 XM_011538439 XP_011536741 XM_011538440 XP_011536742 NM_016281 NP_057365 |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Note=Also localized to the peripheral cell membrane. |
| Tissue Specificity | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. {ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:13679851}. |
| Top Pathways | MAPK signaling pathway |