TAOK3

Gene Symbol	TAOK3
Entrez Gene	51347
Alt Symbol	DPK, JIK, MAP3K18
Species	Human
Gene Type	protein-coding
Description	TAO kinase 3
Other Description	CTCL-associated antigen HD-CL-09|JNK/SAPK-inhibitory kinase|STE20-like kinase|cutaneous T-cell lymphoma-associated antigen HD-CL-09|dendritic cell-derived protein kinase|hKFC-A|jun kinase-inhibitory kinase|kinase from chicken homolog A|serine/threonine-protein kinase TAO3|thousand and one amino acid protein 3
Swissprots	Q9NZM9 Q9HC79 Q8IUM4 Q9UHG7 Q658N1 Q9H2K8
Accessions	CBX51415 EAW98124 EAW98125 Q9H2K8 AA744362 AF135158 AAG09131 AF161373 AAF28933 AF179867 AAF14559 AF181985 AAF25817 AF263311 AAG38501 AF328731 AAN09723 AI057643 AK056370 BAG51691 AK289558 BAF82247 AL833460 AL833731 CAH56239 BC002756 AAH02756 BT007185 AAP35849 BX649175 DB066061 DQ890696 ABM81622 DQ893881 ABM84807 XM_005253897 XP_005253954 XM_005253898 XP_005253955 XM_006719445 XP_006719508 XM_006719446 XP_006719509 XM_011538437 XP_011536739 XM_011538438 XP_011536740 XM_011538439 XP_011536741 XM_011538440 XP_011536742 NM_016281 NP_057365
Function	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Note=Also localized to the peripheral cell membrane.
Tissue Specificity	Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. {ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:13679851}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human JIK protein fragment - ab125551 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human JIK full length protein - ab153348 from Abcam Category Protein Source Wheat germ Species Human

Human JIK protein fragment - ab153349 from Abcam Category Protein Source Wheat germ Species Human

JIK peptide - ab45608 from Abcam Category Peptide

TAOK3 / JIK Antibody Blocking Peptide - LS-E4930 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAOK3 / JIK Antibody Blocking Peptide - LS-E25757 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JIK Partial Recombinant Protein - H00051347-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human JIK Protein - H00051347-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

JIK Recombinant Protein - P4781 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

JIK Peptide - P2874 from Novus Biologicals Category Peptide Species Human

JIK-Antibody-C-term-Blocking-Peptide - BP7902a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JIK blocking peptide - GTX89693-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

TAOK3 Immunizing peptide - orb16805 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

JIK Blocking Peptide - abx063858 from Abbexa Category Peptide Species Human, Mouse, Rat

JIK Peptide - AC21-0586-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TAO kinase 3 (TAOK3) - H00051347-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

TAO kinase 3 (TAOK3) - H00051347-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TAO kinase 3 (TAOK3) - H00051347-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TAO kinase 3 (TAOK3) - P4781 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

TAO kinase 3 (TAOK3) - P5743 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

JIK Peptide - 45-787P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

TAOK3 fusion protein - Ag17869 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TAOK3 fusion protein - ag0211 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TAO Kinase 3 - TAOK3-733H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human TAOK3, His & GST tagged - TAOK3-962H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

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