TAOK3

Gene Symbol TAOK3
Entrez Gene 51347
Alt Symbol DPK, JIK, MAP3K18
Species Human
Gene Type protein-coding
Description TAO kinase 3
Other Description CTCL-associated antigen HD-CL-09|JNK/SAPK-inhibitory kinase|STE20-like kinase|cutaneous T-cell lymphoma-associated antigen HD-CL-09|dendritic cell-derived protein kinase|hKFC-A|jun kinase-inhibitory kinase|kinase from chicken homolog A|serine/threonine-protein kinase TAO3|thousand and one amino acid protein 3
Swissprots Q9NZM9 Q9HC79 Q8IUM4 Q9UHG7 Q658N1 Q9H2K8
Accessions CBX51415 EAW98124 EAW98125 Q9H2K8 AA744362 AF135158 AAG09131 AF161373 AAF28933 AF179867 AAF14559 AF181985 AAF25817 AF263311 AAG38501 AF328731 AAN09723 AI057643 AK056370 BAG51691 AK289558 BAF82247 AL833460 AL833731 CAH56239 BC002756 AAH02756 BT007185 AAP35849 BX649175 DB066061 DQ890696 ABM81622 DQ893881 ABM84807 XM_005253897 XP_005253954 XM_005253898 XP_005253955 XM_006719445 XP_006719508 XM_006719446 XP_006719509 XM_011538437 XP_011536739 XM_011538438 XP_011536740 XM_011538439 XP_011536741 XM_011538440 XP_011536742 NM_016281 NP_057365
Function Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Note=Also localized to the peripheral cell membrane.
Tissue Specificity Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. {ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:13679851}.
Top Pathways MAPK signaling pathway

JIK CRISPR/Cas9 KO Plasmid (h) - sc-408228 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK HDR Plasmid (h) - sc-408228-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK Double Nickase Plasmid (h) - sc-408228-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK Double Nickase Plasmid (h2) - sc-408228-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK CRISPR Activation Plasmid (h) - sc-408228-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK CRISPR Activation Plasmid (h2) - sc-408228-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK Lentiviral Activation Particles (h) - sc-408228-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK Lentiviral Activation Particles (h2) - sc-408228-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JIK siRNA (h) - sc-60871 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

JIK shRNA Plasmid (h) - sc-60871-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

JIK shRNA (h) Lentiviral Particles - sc-60871-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU145631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2244 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2243 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2245 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN20996 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20996 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08559 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08559

TAOK3 siRNA (Human) - CRH9715 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

JIK RNAi - H00051347-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TAOK3 - MBS8220043 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TAOK3 (NM_016281.3) - SHH423000 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TAOK1(NM_020791.1) - SHL055902 from Creative biogene

Category siRNA
Species Reactivities Human

Human TAOK3 siRNA - orb270217 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TAOK3 shRNA Plasmid (Human) - CHH9715 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
Search more