| Gene Symbol |
DBR1
|
| Entrez Gene |
51163
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
debranching RNA lariats 1
|
| Other Description |
RNA lariat debranching enzyme|debranching enzyme homolog 1|lariat debranching enzyme
|
| Swissprots |
Q96GH0 Q9NXQ6 Q9UK59
|
| Accessions |
EAW79083 Q9UK59 AF180919 AAD53327 AK000116 BAA90954 AK094147 BAG52827 AL702928 BC009472 AAH09472 BF987317 BM150284 CD677175 DQ895420 ABM86346 EU176332 ABW03783 NM_016216 NP_057300
|
| Function |
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: DBR1 Overexpression Lysate (Adult Normal) [NBP2-07069] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DBR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8643_DBR1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07069-img0001.jpg)