Gene Symbol | DBR1 |
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Entrez Gene | 51163 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | debranching RNA lariats 1 |
Other Description | RNA lariat debranching enzyme|debranching enzyme homolog 1|lariat debranching enzyme |
Swissprots | Q96GH0 Q9NXQ6 Q9UK59 |
Accessions | EAW79083 Q9UK59 AF180919 AAD53327 AK000116 BAA90954 AK094147 BAG52827 AL702928 BC009472 AAH09472 BF987317 BM150284 CD677175 DQ895420 ABM86346 EU176332 ABW03783 NM_016216 NP_057300 |
Function | Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320}. |
Subcellular Location | Nucleus {ECO:0000305}. |
DBR1 CRISPR/Cas9 KO Plasmid (h) - sc-407375 from Santa Cruz Biotechnology
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DBR1 HDR Plasmid (h) - sc-407375-HDR from Santa Cruz Biotechnology
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DBR1 Double Nickase Plasmid (h) - sc-407375-NIC from Santa Cruz Biotechnology
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DBR1 Double Nickase Plasmid (h2) - sc-407375-NIC-2 from Santa Cruz Biotechnology
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DBR1 CRISPR Activation Plasmid (h) - sc-407375-ACT from Santa Cruz Biotechnology
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DBR1 CRISPR Activation Plasmid (h2) - sc-407375-ACT-2 from Santa Cruz Biotechnology
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DBR1 Lentiviral Activation Particles (h) - sc-407375-LAC from Santa Cruz Biotechnology
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DBR1 Lentiviral Activation Particles (h2) - sc-407375-LAC-2 from Santa Cruz Biotechnology
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DBR1 siRNA (h) - sc-77921 from Santa Cruz Biotechnology
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DBR1 shRNA Plasmid (h) - sc-77921-SH from Santa Cruz Biotechnology
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DBR1 shRNA (h) Lentiviral Particles - sc-77921-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU132661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6953 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6953 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06817 from Sigma-Aldrich
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DBR1 siRNA (Human) - CRH9574 from Cohesion Biosciences
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DBR1 - MBS8217290 from MyBioSource
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DBR1 CRISPR/Cas9 KO Plasmid (h2) - sc-407375-KO-2 from Santa Cruz Biotechnology
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DBR1 HDR Plasmid (h2) - sc-407375-HDR-2 from Santa Cruz Biotechnology
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Human DBR1 siRNA - orb270076 from Biorbyt
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DBR1 shRNA Plasmid (Human) - CHH9574 from Cohesion Biosciences
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DBR1 miRNA 3'UTR clone - MiUTR3H-08907 from Creative biogene
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