AWAT2

Gene Symbol AWAT2
Entrez Gene 158835
Alt Symbol ARAT, DC4, DGAT2L4, MFAT, WS
Species Human
Gene Type protein-coding
Description acyl-CoA wax alcohol acyltransferase 2
Other Description acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase 2-like protein 4|diacylglycerol O-acyltransferase candidate 4|long-chain-alcohol O-fatty-acyltransferase 2|multifunctional O-acyltransferase|retinol O-fatty-acyltransferase
Swissprots Q6E213 Q6P437 Q6IEE3
Accessions EAX05358 Q6E213 AY605053 AAT68764 BC063698 AAH63698 BC146452 AAI46453 BC153070 AAI53071 BN000156 CAD89267 XM_011530876 XP_011529178 NM_001002254 NP_001002254
Function Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15220349}; Multi-pass membrane protein {ECO:0000269|PubMed:15220349}.
Tissue Specificity Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
Top Pathways Vitamin digestion and absorption, Retinol metabolism

AWAT2 (T-12) - sc-161526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DGAT2L4 antibody - ab83182 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DGAT2L4 antibody (ab83182) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DGAT2L4 antibody - ab168584 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DGAT2L4 antibody (ab168584) at 1 ��g/mlLane 1 : DGAT2L4 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335) - LS-C156696 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AWAT2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, PE) - LS-C252154 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, Azide-free, HRP) - LS-C252153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, AP) - LS-C252931 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, APC) - LS-C252932 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, Biotin) - LS-C252933 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (C-Terminus) - LS-C82474 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335, FITC) - LS-C252938 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AWAT2 / DGAT2L4 Antibody (aa306-335) - LS-C319726 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

AWAT2 Antibody - NBP1-91574 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AWAT2 Antibody - NBP2-38003 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: AWAT2 Antibody [NBP2-38003] - Staining of human skin shows moderate cytoplasmic positivity in sebaceous glands.

AWAT2 Antibody - H00158835-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

ANTI-AWAT2 (C-TERM) antibody produced in rabbit - SAB1303300 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AWAT2 (C-term): <B>Cat. No. SAB1303300 </B>: AWAT2 Antibody (C-term) western blot analysis in tissue lysates (35 μg/lane).<BR/><B>Lanes:</B><BR/>1. mouse liver<BR/>2. spleen

Anti-DGAT2L4 antibody produced in rabbit - SAB2100565 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DGAT2L4: <B>Cat. No.SAB2100565</B>: DGAT2L4 in Fetal Brain tissue lysate with DGAT2L4 antibody at 1.0 μg/mL.

DGAT2L4 antibody - C-terminal region (ARP44425_P050) - ARP44425_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AWAT2 Antibody - C-terminal region (OAAB00842) - OAAB00842 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

AWAT2-Antibody-C-term - AP10826b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
AWAT2 Antibody (C-term) (Cat. #AP10826b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AWAT2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

DGAT2L4 antibody, C-term - GTX46730 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-DGAT2L4 antibody, C-term used in Western blot. GTX46730
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