AWAT2

Gene Symbol AWAT2
Entrez Gene 158835
Alt Symbol ARAT, DC4, DGAT2L4, MFAT, WS
Species Human
Gene Type protein-coding
Description acyl-CoA wax alcohol acyltransferase 2
Other Description acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase 2-like protein 4|diacylglycerol O-acyltransferase candidate 4|long-chain-alcohol O-fatty-acyltransferase 2|multifunctional O-acyltransferase|retinol O-fatty-acyltransferase
Swissprots Q6E213 Q6P437 Q6IEE3
Accessions EAX05358 Q6E213 AY605053 AAT68764 BC063698 AAH63698 BC146452 AAI46453 BC153070 AAI53071 BN000156 CAD89267 XM_011530876 XP_011529178 NM_001002254 NP_001002254
Function Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15220349}; Multi-pass membrane protein {ECO:0000269|PubMed:15220349}.
Tissue Specificity Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
Top Pathways Vitamin digestion and absorption, Retinol metabolism

AWAT2 CRISPR/Cas9 KO Plasmid (h) - sc-404122 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 HDR Plasmid (h) - sc-404122-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 Double Nickase Plasmid (h) - sc-404122-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 Double Nickase Plasmid (h2) - sc-404122-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 CRISPR Activation Plasmid (h) - sc-404122-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 CRISPR Activation Plasmid (h2) - sc-404122-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 Lentiviral Activation Particles (h) - sc-404122-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 Lentiviral Activation Particles (h2) - sc-404122-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AWAT2 siRNA (h) - sc-90922 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AWAT2 shRNA Plasmid (h) - sc-90922-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AWAT2 shRNA (h) Lentiviral Particles - sc-90922-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN3784 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3784 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08407 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08407

AWAT2 siRNA (Human) - CRJ5879 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AWAT2 - MBS8206826 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AWAT2 (NM_001002254.1) - SHH243922 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DGAT2L4(NM_001002254.1) - SHG087577 from Creative biogene

Category siRNA
Species Reactivities Human

AWAT2 shRNA Plasmid (Human) - CHJ5879 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AWAT2 miRNA 3'UTR clone - MiUTR1H-02792 from Creative biogene

Species Reactivities Human
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