| Gene Symbol |
AWAT2
|
| Entrez Gene |
158835
|
| Alt Symbol |
ARAT, DC4, DGAT2L4, MFAT, WS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA wax alcohol acyltransferase 2
|
| Other Description |
acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase 2-like protein 4|diacylglycerol O-acyltransferase candidate 4|long-chain-alcohol O-fatty-acyltransferase 2|multifunctional O-acyltransferase|retinol O-fatty-acyltransferase
|
| Swissprots |
Q6E213 Q6P437 Q6IEE3
|
| Accessions |
EAX05358 Q6E213 AY605053 AAT68764 BC063698 AAH63698 BC146452 AAI46453 BC153070 AAI53071 BN000156 CAD89267 XM_011530876 XP_011529178 NM_001002254 NP_001002254
|
| Function |
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15220349}; Multi-pass membrane protein {ECO:0000269|PubMed:15220349}.
|
| Tissue Specificity |
Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}.
|
| Top Pathways |
Vitamin digestion and absorption, Retinol metabolism
|