Gene Symbol |
GPI
|
Entrez Gene |
2821
|
Alt Symbol |
AMF, GNPI, NLK, PGI, PHI, SA-36, SA36
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
glucose-6-phosphate isomerase
|
Other Description |
autocrine motility factor|glucose phosphate isomerase|hexose monophosphate isomerase|hexosephosphate isomerase|neuroleukin|oxoisomerase|phosphoglucose isomerase|phosphohexomutase|phosphohexose isomerase|phosphosaccharomutase|sperm antigen 36|sperm antigen-36
|
Swissprots |
Q9BSK5 Q9BRD3 Q9UHE6 B4DG39 P06744
|
Accessions |
AAP72966 P06744 AB209575 BAD92812 AK025421 AK129884 AK130102 AK293446 BAG56947 AK294396 BAG57650 AK301103 BAG62702 BC004982 AAH04982 BC006342 BM664761 BX641158 CR745343 DC299841 DC342043 DQ892924 ABM83850 DQ896173 ABM87172 FY213211 K03515 AAA36368 X16539 XM_005258764 XP_005258821 XM_006723148 XP_006723211 XM_011526754 XP_011525056 XM_011526755 XP_011525057 NM_000175 NP_000166 NM_001184722 NP_001171651 NM_001289789 NP_001276718 NM_001289790 NP_001276719
|
Function |
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
|
Top Pathways |
Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Carbon metabolism, Starch and sucrose metabolism
|