Gene Symbol | GPI |
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Entrez Gene | 2821 |
Alt Symbol | AMF, GNPI, NLK, PGI, PHI, SA-36, SA36 |
Species | Human |
Gene Type | protein-coding |
Description | glucose-6-phosphate isomerase |
Other Description | autocrine motility factor|glucose phosphate isomerase|hexose monophosphate isomerase|hexosephosphate isomerase|neuroleukin|oxoisomerase|phosphoglucose isomerase|phosphohexomutase|phosphohexose isomerase|phosphosaccharomutase|sperm antigen 36|sperm antigen-36 |
Swissprots | Q9BSK5 Q9BRD3 Q9UHE6 B4DG39 P06744 |
Accessions | AAP72966 P06744 AB209575 BAD92812 AK025421 AK129884 AK130102 AK293446 BAG56947 AK294396 BAG57650 AK301103 BAG62702 BC004982 AAH04982 BC006342 BM664761 BX641158 CR745343 DC299841 DC342043 DQ892924 ABM83850 DQ896173 ABM87172 FY213211 K03515 AAA36368 X16539 XM_005258764 XP_005258821 XM_006723148 XP_006723211 XM_011526754 XP_011525056 XM_011526755 XP_011525057 NM_000175 NP_000166 NM_001184722 NP_001171651 NM_001289789 NP_001276718 NM_001289790 NP_001276719 |
Function | Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}. |
Top Pathways | Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Carbon metabolism, Starch and sucrose metabolism |
GPI CRISPR/Cas9 KO Plasmid (h) - sc-402796 from Santa Cruz Biotechnology
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GPI HDR Plasmid (h) - sc-402796-HDR from Santa Cruz Biotechnology
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GPI Double Nickase Plasmid (h) - sc-402796-NIC from Santa Cruz Biotechnology
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GPI Double Nickase Plasmid (h2) - sc-402796-NIC-2 from Santa Cruz Biotechnology
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GPI CRISPR Activation Plasmid (h) - sc-402796-ACT from Santa Cruz Biotechnology
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GPI CRISPR Activation Plasmid (h2) - sc-402796-ACT-2 from Santa Cruz Biotechnology
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GPI Lentiviral Activation Particles (h) - sc-402796-LAC from Santa Cruz Biotechnology
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GPI Lentiviral Activation Particles (h2) - sc-402796-LAC-2 from Santa Cruz Biotechnology
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GPI siRNA (h) - sc-43810 from Santa Cruz Biotechnology
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GPI shRNA Plasmid (h) - sc-43810-SH from Santa Cruz Biotechnology
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GPI shRNA (h) Lentiviral Particles - sc-43810-V from Santa Cruz Biotechnology
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NLK RNAi - H00051701-R03 from Novus Biologicals
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MISSION® esiRNA - EHU078901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9528 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9528 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02591 from Sigma-Aldrich
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GPI siRNA (Human) - CRH1886 from Cohesion Biosciences
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GPI - MBS8235994 from MyBioSource
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shRNA set against Human GPI (NM_000175.3) - SHH305898 from Creative biogene
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GPI shRNA Plasmid (Human) - CHH1886 from Cohesion Biosciences
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GPI miRNA 3'UTR clone - MiUTR3H-01736 from Creative biogene
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