PBX1

Gene Symbol PBX1
Entrez Gene 5087
Alt Symbol -
Species Human
Gene Type protein-coding
Description pre-B-cell leukemia homeobox 1
Other Description homeobox protein PBX1|homeobox protein PRL|pre-B-cell leukemia transcription factor 1
Swissprots P40424 Q5T488 F5H4U9 B4DSC1
Accessions AAG30941 EAW90738 EAW90739 EAW90740 EAW90741 P40424 AK022520 AK022962 AK291415 BAF84104 AK299673 BAG61583 AK301540 BAH13510 AL049381 BC044624 BC101578 AAI01579 BC143435 BC143451 BT006705 AAP35351 BX647313 CR749446 CAH18284 DA483403 DA492007 DA760179 DA770191 DB270853 DB289928 M31170 AAA36484 M86546 AAA60031 XM_005245228 XP_005245285 XM_005245229 XP_005245286 XM_005245230 XP_005245287 XM_006711347 XP_006711410 XM_011509590 XP_011507892 XM_011509591 XP_011507893 XM_011509592 XP_011507894 XM_011509593 XP_011507895 XM_011509594 XP_011507896 XM_011509595 XP_011507897 XM_011509596 XP_011507898 NM_001204961 NP_001191890 NM_001204963 NP_001191892 NM_002585 NP_002576
Function Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Tissue Specificity Expressed in all tissues except in cells of the B and T lineage.
Top Pathways Transcriptional misregulation in cancer

Pbx1 Antibody - 4342 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from E10.5 mouse Pbx1 heterozygote or null emrbryos. Image kindly provided by Dr. Sheldon Rowan, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School.

Pbx 1 (P-20) - sc-889 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pbx 1 (P-20): sc-889. Western blot analysis of Pbx 1 expression in KNRK nuclear extract.

Pbx 1a (710.2) - sc-101851 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Pbx 1b (41.1) - sc-101852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pbx 1b (41.1): sc-101852. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing nuclear staining of ovarian stroma cells.

Pbx 1/2/3 (C-20) - sc-888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pbx 1/2/3 (C-20): sc-888. Western blot analysis of Pbx family members in BJAB (A), A-673 (B) and A-431 (C) whole cell lysates.

Pbx 1a/2/3a (359.15) - sc-101856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pbx 1a/2/3a (359.15): sc-101856. Western blot analysis of Pbx 3 expression in non-transfected 293T: sc-117752 (A), human Pbx 3 transfected 293T: sc-111640 (B) and BJAB (C) whole cell lysates.

Pbx 1/2/3/4 (H-260) - sc-25411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pbx 1/2/3/4 (H-260): sc-25411. Western blot analysis of Pbx 1 expression in non-transfected: sc-117752 (A) and mouse Pbx 1 transfected: sc-122409 (B) 293T whole cell lysates.

Pbx 1/2/3/4 (E-12) - sc-48423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pbx 1/2/3/4 (E-12): sc-48423. Western blot analysis of Pbx 1/2/3/4 expression in Jurkat nuclear extract.

Pbx 1/2/3/4 (F-3) - sc-28313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pbx 1/2/3/4 (F-3): sc-28313. Western blot analysis of Pbx 1/2/3/4 expression in Jurkat nuclear extract (A) and BJAB whole cell lysate (B).

Anti-PBX1 antibody [146C1a] - ab66496 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 146C1a

Anti-PBX1 antibody [1D9] - ab119069 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D9
All lanes : Anti-PBX1 antibody [1D9] (ab119069) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY PBX1 cDNALysates/proteins at 5 µg per lane.

Anti-PBX1 antibody [EPR15937] - ab192606 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15937
Immunoprecipitation of Hela cell lysates (+) or PBS control (-) labeling PBX1 using ab192606 at 1/50 dilution and Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1500 as secondary.

Anti-PBX1 Antibody (N-Terminus) - LS-C74189 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PBX1 Antibody - LS-C74190 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PBX1 Antibody (N-Terminus) - LS-C40287 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-PBX1 Antibody (aa213-322, Azide-free) - LS-C328159 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PBX1 Antibody (aa313-327) - LS-C113024 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PBX1 antibody (0.5 ug/ml) staining of K562 lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PBX1 Antibody (clone 146C1a) - LS-C184617 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 146C1a
Western blot of immunized recombinant protein using PBX1 antibody.

Anti-PBX1 Antibody - LS-C330800 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of A2780 cell line, using PBX1 antibody.

Anti-PBX1 Antibody (clone 146C1a) - LS-C342648 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 146C1a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-PBX1 mAb.

Anti-PBX1 Antibody (clone 1H5) - LS-C337367 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H5
Anti-PBX1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1.

Anti-PBX1 Antibody (clone 1D9) - LS-C172991 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D9
Anti-PBX1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1.

Anti-PBX1 Antibody (clone 4D1) - LS-C173146 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D1
Anti-PBX1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1.

Anti-PBX1 Antibody (clone 4A2) - LS-C133363 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A2
Immunoperoxidase of monoclonal antibody to PBX1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml]

Anti-PBX1 Antibody (clone 1C11) - LS-C173044 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C11
IHC of paraffin-embedded Human liver tissue using anti-PBX1 mouse monoclonal antibody.
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