PBX1

Gene Symbol PBX1
Entrez Gene 5087
Alt Symbol -
Species Human
Gene Type protein-coding
Description pre-B-cell leukemia homeobox 1
Other Description homeobox protein PBX1|homeobox protein PRL|pre-B-cell leukemia transcription factor 1
Swissprots P40424 Q5T488 F5H4U9 B4DSC1
Accessions AAG30941 EAW90738 EAW90739 EAW90740 EAW90741 P40424 AK022520 AK022962 AK291415 BAF84104 AK299673 BAG61583 AK301540 BAH13510 AL049381 BC044624 BC101578 AAI01579 BC143435 BC143451 BT006705 AAP35351 BX647313 CR749446 CAH18284 DA483403 DA492007 DA760179 DA770191 DB270853 DB289928 M31170 AAA36484 M86546 AAA60031 XM_005245228 XP_005245285 XM_005245229 XP_005245286 XM_005245230 XP_005245287 XM_006711347 XP_006711410 XM_011509590 XP_011507892 XM_011509591 XP_011507893 XM_011509592 XP_011507894 XM_011509593 XP_011507895 XM_011509594 XP_011507896 XM_011509595 XP_011507897 XM_011509596 XP_011507898 NM_001204961 NP_001191890 NM_001204963 NP_001191892 NM_002585 NP_002576
Function Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Tissue Specificity Expressed in all tissues except in cells of the B and T lineage.
Top Pathways Transcriptional misregulation in cancer

Pre-B-cell leukemia transcription factor 1, ELISA Kit - MBS280807 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PBX1 ELISA Kit - E030447 from Biobool

Category ELISA Kit

anti-PBX1 antibody - ARG65262 from Arigo Biolaboratories

Category ELISA Kit

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9366580 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9350312 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9344746 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9358124 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9363411 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9354029 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9360601 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9356400 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9344254 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9360446 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9362329 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9344852 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9343709 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9367730 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9364656 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9360818 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9371592 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9348243 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9350847 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9343520 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1), ELISA Kit - MBS9345716 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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