PBX1

Gene Symbol	PBX1
Entrez Gene	5087
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pre-B-cell leukemia homeobox 1
Other Description	homeobox protein PBX1|homeobox protein PRL|pre-B-cell leukemia transcription factor 1
Swissprots	P40424 Q5T488 F5H4U9 B4DSC1
Accessions	AAG30941 EAW90738 EAW90739 EAW90740 EAW90741 P40424 AK022520 AK022962 AK291415 BAF84104 AK299673 BAG61583 AK301540 BAH13510 AL049381 BC044624 BC101578 AAI01579 BC143435 BC143451 BT006705 AAP35351 BX647313 CR749446 CAH18284 DA483403 DA492007 DA760179 DA770191 DB270853 DB289928 M31170 AAA36484 M86546 AAA60031 XM_005245228 XP_005245285 XM_005245229 XP_005245286 XM_005245230 XP_005245287 XM_006711347 XP_006711410 XM_011509590 XP_011507892 XM_011509591 XP_011507893 XM_011509592 XP_011507894 XM_011509593 XP_011507895 XM_011509594 XP_011507896 XM_011509595 XP_011507897 XM_011509596 XP_011507898 NM_001204961 NP_001191890 NM_001204963 NP_001191892 NM_002585 NP_002576
Function	Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Tissue Specificity	Expressed in all tissues except in cells of the B and T lineage.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PBX1 protein fragment - ab159054 from Abcam Category Protein Source Wheat germ Species Human

PBX1 Antibody Blocking Peptide - LS-E10778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PBX1 Antibody Blocking Peptide - LS-E27373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PBX1 Protein - H00005087-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PBX1 blocking peptide - GTX88088-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

PBX1 Peptide - AC21-2198-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PBX1 - H00005087-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PBX1 - H00005087-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PBX1 Peptide - 42-589P from ProSci Category Peptide Species Human, Mouse, Rat

PBX1 fusion protein - ag12535 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PBX1 fusion protein - ag12817 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PBX1 fusion protein - Ag17765 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Pre-B-cell leukemia transcription factor 1(PBX1) - CSB-YP017505HU CSB-EP017505HU CSB-BP017505HU CSB-MP017505HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PBX1 Protein - abx164425 from Abbexa Category Protein Species Human, Mouse, Rat

Pre-B-cell leukemia homeobox 1 (PBX1) - TP310944 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Pre-B-cell leukemia transcription factor 1 (PBX1), Recombinant Protein - MBS956237 from MyBioSource Category Protein Prices $1,205.00, $1,205.00, $1,425.00, $1,425.00, $1,950.00, $1,950.00, $2,415.00, $2,415.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PBX1, Peptide - MBS427364 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

PBX1 Protein - NBP1-85803PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PBX1 Recombinant Protein Antigen - NBP1-86151PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PBX1-Antibody-C-term-Blocking-Peptide - BP7285b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PBX1-Antibody-N-term-Blocking-Peptide - BP7285a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PBX1 Peptide, Human - M34GP11354H from Creative Peptides Category Peptide Source Synthetic. Species Human

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