KCNJ11
| Gene Symbol | KCNJ11 |
|---|---|
| Entrez Gene | 3767 |
| Alt Symbol | BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 11 |
| Other Description | ATP-sensitive inward rectifier potassium channel 11|beta-cell inward rectifier subunit|inward rectifier K(+) channel Kir6.2|inwardly rectifying potassium channel KIR6.2|potassium channel inwardly rectifing subfamily J member 11|potassium channel, inwardly rectifying subfamily J member 11|potassium inwardly-rectifying channel, subfamily J, member 11 |
| Swissprots | Q58EX3 Q2M1H7 Q8IW96 E9PNK0 B4DWI4 Q14654 |
| Accessions | ACR44082 ACR44083 ACZ56124 AHB14393 AHB14394 AHB14395 BAA09131 EAW68438 Q14654 AI377272 AK301550 BAG63046 AK314943 BAG37449 BC040617 AAH40617 BC064497 AAH64497 BC112358 AAI12359 BE019467 XM_006718226 XP_006718289 XR_930867 NM_000525 NP_000516 NM_001166290 NP_001159762 |
| Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000250, ECO:0000269|PubMed:17855752, ECO:0000269|PubMed:9831708}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Top Pathways | Type II diabetes mellitus |
KIR6.2 CRISPR/Cas9 KO Plasmid (h) - sc-401139 from Santa Cruz Biotechnology
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KIR6.2 HDR Plasmid (h) - sc-401139-HDR from Santa Cruz Biotechnology
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KIR6.2 Double Nickase Plasmid (h) - sc-401139-NIC from Santa Cruz Biotechnology
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KIR6.2 Double Nickase Plasmid (h2) - sc-401139-NIC-2 from Santa Cruz Biotechnology
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KIR6.2 CRISPR Activation Plasmid (h) - sc-401139-ACT from Santa Cruz Biotechnology
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KIR6.2 CRISPR Activation Plasmid (h2) - sc-401139-ACT-2 from Santa Cruz Biotechnology
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KIR6.2 Lentiviral Activation Particles (h) - sc-401139-LAC from Santa Cruz Biotechnology
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KIR6.2 Lentiviral Activation Particles (h2) - sc-401139-LAC-2 from Santa Cruz Biotechnology
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KIR6.2 siRNA (h) - sc-42628 from Santa Cruz Biotechnology
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KIR6.2 shRNA Plasmid (h) - sc-42628-SH from Santa Cruz Biotechnology
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KIR6.2 shRNA (h) Lentiviral Particles - sc-42628-V from Santa Cruz Biotechnology
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Kir6.2 RNAi - H00003767-R01 from Novus Biologicals
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MISSION® esiRNA - EHU035241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1733 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1733 from Sigma-Aldrich
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KCNJ11 siRNA (Human) - CRH2543 from Cohesion Biosciences
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KCNJ11, siRNA - MBS8218373 from MyBioSource
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KCNJ11, siRNA - MBS8210557 from MyBioSource
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KCNJ11, siRNA - MBS8233687 from MyBioSource
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shRNA set against Human KCNJ11 (NM_000525.3) - SHH323203 from Creative biogene
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shRNA set against Human KCNJ11(NM_000525.3) - SHL189750 from Creative biogene
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Human KCNJ11 siRNA - orb263045 from Biorbyt
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KCNJ11 shRNA Plasmid (Human) - CHH2543 from Cohesion Biosciences
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KCNJ11 miRNA 3'UTR clone - MiUTR1H-05134 from Creative biogene
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KCNJ11 miRNA 3'UTR clone - MiUTR3H-03754 from Creative biogene
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