KCNJ11

Gene Symbol	KCNJ11
Entrez Gene	3767
Alt Symbol	BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Species	Human
Gene Type	protein-coding
Description	potassium channel, inwardly rectifying subfamily J, member 11
Other Description	ATP-sensitive inward rectifier potassium channel 11|beta-cell inward rectifier subunit|inward rectifier K(+) channel Kir6.2|inwardly rectifying potassium channel KIR6.2|potassium channel inwardly rectifing subfamily J member 11|potassium channel, inwardly rectifying subfamily J member 11|potassium inwardly-rectifying channel, subfamily J, member 11
Swissprots	Q58EX3 Q2M1H7 Q8IW96 E9PNK0 B4DWI4 Q14654
Accessions	ACR44082 ACR44083 ACZ56124 AHB14393 AHB14394 AHB14395 BAA09131 EAW68438 Q14654 AI377272 AK301550 BAG63046 AK314943 BAG37449 BC040617 AAH40617 BC064497 AAH64497 BC112358 AAI12359 BE019467 XM_006718226 XP_006718289 XR_930867 NM_000525 NP_000516 NM_001166290 NP_001159762
Function	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000250, ECO:0000269|PubMed:17855752, ECO:0000269|PubMed:9831708}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Top Pathways	Type II diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kir6.2 full length protein - ab132695 from Abcam Category Protein Source Wheat germ Species Human

Human Kir6.2 peptide - ab98914 from Abcam Category Peptide

Human Kir6.2 protein fragment - ab114436 from Abcam Category Protein Source Wheat germ Species Human

KCNJ11 / Kir6.2 Antibody Blocking Peptide - LS-E6026 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNJ11 / Kir6.2 Antibody Blocking Peptide - LS-E26331 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNJ11 / Kir6.2 Antibody Blocking Peptide - LS-E26332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNJ11 / Kir6.2 Antibody Blocking Peptide - LS-E10006 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Kir6.2 Partial Recombinant Protein - H00003767-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Kir6.2 Recombinant Protein - H00003767-P01 from Novus Biologicals Category Protein

KCNJ11-Antibody-N-term-Blocking-Peptide - BP9209a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Kir6.2 blocking peptide - GTX88908-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Kir6.2 blocking peptide - GTX88845-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

kir6.2 Peptide - AC21-1166-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

kir6.2 Peptide - AC21-1167-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KCNJ11 - H00003767-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KCNJ11 - H00003767-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KCNJ11 - H00003767-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KCNJ11 Peptide - 46-679P from ProSci Category Peptide Species Human

Kir6.2 fusion protein - Ag10368 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Kir6.2 fusion protein - Ag10262 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human KCNJ11 - KCNJ11-29900TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human KCNJ11 - KCNJ11-498H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Kir6.2 Blocking Peptide - CBP4045 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Pig, Rabbit

Kir6.2 (V220) Peptide - BS2641P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant ATP Binding Cassette Transporter C8 (ABCC8) - RPD628Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Search more