KCNIP2

Gene Symbol	KCNIP2
Entrez Gene	30819
Alt Symbol	KCHIP2
Species	Human
Gene Type	protein-coding
Description	Kv channel interacting protein 2
Other Description	A-type potassium channel modulatory protein 2\|Kv channel-interacting protein 2\|cardiac voltage-gated potassium channel modulatory subunit\|potassium channel-interacting protein 2
Swissprots	Q96T43 Q3YAC8 Q96T44 Q7Z6F1 A8MQ75 Q9HD11 Q9NY10 Q9H0N4 Q3YAC9 A6NJE5 Q9NZI1 Q3YAC6 Q96T42 Q9NS61 Q96K86 Q9NS60 Q96T41 Q9HD10
Accessions	AAK21972 AAX58112 EAW49730 EAW49731 EAW49732 EAW49733 EAW49734 EAW49735 EAW49736 EAW49737 EAW49738 EAW49739 EAW49740 Q9NS61 AB044584 BAA96740 AB044585 BAA96741 AF199598 AAF33683 AF295076 AAG02120 AF295530 AAG02121 AF347114 AAK70356 AF367018 AAK53707 AF367019 AAK53708 AF367020 AAK53709 AF367021 AAK53710 AJ276317 CAB77054 AK027347 BAB55052 AK055089 BAG51465 AK094668 BAG52907 AK125382 AK130689 AK295324 BAG58301 AK301433 BAG62961 AK309368 AK314536 AK315042 BAG37523 AL136722 CAB66656 AM392816 CAL37694 AY026328 AAK07674 AY302141 AAP57633 BC034685 AAH34685 BG911444 DQ148480 AAZ77797 DQ148481 AAZ77798 DQ148482 AAZ77799 DQ148483 AAZ77800 DQ148484 AAZ77801 DQ862463 ABI51986 XM_005269729 XP_005269786 XM_005269730 XP_005269787 XM_006717812 XP_006717875 XM_011539731 XP_011538033 NM_014591 NP_055406 NM_173191 NP_775283 NM_173192 NP_775284 NM_173193 NP_775285 NM_173194 NP_775286 NM_173195 NP_775287 NM_173197 NP_775289 NM_173342
Function	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). {ECO:0000250\|UniProtKB:Q9JJ69, ECO:0000269\|PubMed:10676964, ECO:0000269\|PubMed:11287421, ECO:0000269\|PubMed:11684073, ECO:0000269\|PubMed:12297301, ECO:0000269\|PubMed:12829703, ECO:0000269\|PubMed:14623880}.
Subcellular Location	Isoform 6: Cell membrane {ECO:0000250\|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250\|UniProtKB:Q9JM59}.
Tissue Specificity	Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO:0000269\|PubMed:11263977, ECO:0000269\|PubMed:11684073, ECO:0000269\|PubMed:15356203}.

KChIP2 (G-13) - sc-26467 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KChIP2 (G-13): sc-26467. Western blot analysis of KChIP2 expression in mouse brain tissue extract.

KChIP2 (D-15) - sc-11251 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KChIP2 (H-100) - sc-25685 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

KChIP2 (H-100): sc-25685. Western blot analysis of KChIP2 expression in mouse heart tissue extract.

KChIP2 (C-12) - sc-26469 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KChIP2 (9K9) - sc-134371 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

KChIP2 (9K9): sc-134371. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing cytoplasmic and membrane localization.

Anti-KChIP2 antibody - ab88542 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-KChIP2 antibody (ab88542) at 1 µg/ml + Rat brain lysate with KChIP2 expression at 50 µg

Anti-KChIP2 antibody - ab57207 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57207 KChIP2 antibody at 1ug/ml.

Anti-KChIP2 antibody [S60-73] - ab99041 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Overlay histogram showing SH-SH5Y cells stained with ab99041 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab99041, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-KChIP2 antibody - Carboxyterminal end - ab66741 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Ab66741 staining human normal pineal gland. Staining is localised to the cell membrane and cytoplasm.Left panel: with primary antibody at 1:1000. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be requi

Anti-KCNIP2 / KCHIP2 Antibody (aa6-24) - LS-C16131 from LifeSpan Bioscience

Prices	$530.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCNIP2 / KCHIP2 Antibody (aa40-89) - LS-C19250 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-KCNIP2 / KCHIP2 Antibody (C-Terminus) - LS-C144794 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KCNIP2 / KCHIP2 Antibody (clone S60-73) - LS-C152696 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Anti-KCNIP2 / KCHIP2 Antibody (N-Terminus) - LS-C203293 from LifeSpan Bioscience

Prices	$245.00
Sizes	40 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCNIP2 / KCHIP2 Antibody (aa22-71) - LS-C19241 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C19241 was used in IHC to stain formalin-fixed, paraffin-embedded human brain.

Anti-KCNIP2 / KCHIP2 Antibody (aa1-252, clone S60-73, Atto 390) - LS-C228196 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Anti-KCNIP2 / KCHIP2 Antibody (aa1-252, clone S60-73, Atto 565) - LS-C228198 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Anti-KCNIP2 / KCHIP2 Antibody (aa1-252, clone S60-73, Atto 488) - LS-C228197 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Anti-KCNIP2 / KCHIP2 Antibody (aa36-85) - LS-C110044 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C110044 Western blot of HeLa lysate.

Anti-KCNIP2 / KCHIP2 Antibody (clone S60-73) - LS-C150420 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S60-73

IHC analysis of KChIP2 in frozen sections of mouse brain extract using KCNIP2 / KCHIP2 antibody.

Anti-KCNIP2 / KCHIP2 Antibody (aa72-121) - LS-C110046 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C110046 Western blot of Jurkat lysate.

Anti-KCNIP2 / KCHIP2 Antibody (aa107-156) - LS-C110045 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C110045 Western blot of Fetal Stomach lysate.

Anti-KCNIP2 / KCHIP2 Antibody (aa35-84) - LS-C110011 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C110011 Western blot of Fetal Stomach lysate.

Anti-KCNIP2 / KCHIP2 Antibody (aa1-252, clone S60-73, Atto 594) - LS-C228199 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S60-73

Anti-KCNIP2 / KCHIP2 Antibody (aa35-84) - LS-C110048 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

KCNIP2 / KCHIP2 antibody LS-C110048 Western blot of Fetal Liver lysate.

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