BACE1

Gene Symbol	BACE1
Entrez Gene	23621
Alt Symbol	ASP2, BACE, HSPC104
Species	Human
Gene Type	protein-coding
Description	beta-site APP-cleaving enzyme 1
Other Description	APP beta-secretase|asp 2|aspartyl protease 2|beta-secretase 1|beta-secretase 1 precursor variant 1|beta-site APP cleaving enzyme 1|beta-site amyloid beta A4 precursor protein-cleaving enzyme|memapsin-2|membrane-associated aspartic protease 2|transmembrane aspartic proteinase Asp2
Swissprots	Q9UJT5 Q9BYB9 E9PE65 P56817 B0YIU9 Q9ULS1 Q9BYC0 Q9BYC1 A0M8W7 H7BXJ9
Accessions	AAO23912 AAY16982 ACA05927 CAI61888 EAW67308 EAW67309 EAW67310 EAW67311 EAW67312 EAW67313 EAW67314 EAW67315 EAW67316 EAW67317 P56817 AB032975 BAA86463 AB050436 BAB40931 AB050437 BAB40932 AB050438 BAB40933 AB089958 BAC81826 AB177847 BAD66825 AF161367 AAF28927 AF190725 AAF04142 AF200193 AAF13715 AF200343 AAF17079 AF201468 AAF18982 AF204943 AAF26367 AF324837 AAM54050 AF338816 AAK38374 AF338817 AAK38375 AF527782 AAM92013 AK075049 BAG52056 AK296015 BAH12238 AK296535 BAH12380 AL833810 CAD38674 BC036084 AAH36084 BC065492 AAH65492 BM996673 BQ005204 DC343475 DQ891509 ABM82435 DQ894700 ABM85626 NM_001207048 NP_001193977 NM_001207049 NP_001193978 NM_012104 NP_036236 NM_138971 NP_620427 NM_138972 NP_620428 NM_138973 NP_620429
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Tissue Specificity	Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:11083922}.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BACE (h): 293T Lysate - sc-159912 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Human BACE1 / ASP2 HEK293 Cell Lysate (WB positive control) - 10064-HCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BACE1 / ASP2 HEK293 Cell Lysate (WB positive control) - 10064-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BACE1 / ASP2 HEK293 Cell Lysate (WB positive control) - 10064-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BACE1 Human Cells Transfected Lysate (positive control) (denatured) - orb172855 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

BACE-1 Overexpression Lysate (Native) - NBP2-04325 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BACE-1 Overexpression Lysate (Denatured) - H00023621-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human BACE1 Human Cells Transfected Lysate (positive control) (denatured) - orb172760 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human BACE1 Human Cells Transfected Lysate (positive control) (denatured) - orb172761 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human BACE1 Knockdown Stable Cell Line - CSC-DC001291 from Creative biogene Category Cell Line Species Human

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