BACE1

Gene Symbol BACE1
Entrez Gene 23621
Alt Symbol ASP2, BACE, HSPC104
Species Human
Gene Type protein-coding
Description beta-site APP-cleaving enzyme 1
Other Description APP beta-secretase|asp 2|aspartyl protease 2|beta-secretase 1|beta-secretase 1 precursor variant 1|beta-site APP cleaving enzyme 1|beta-site amyloid beta A4 precursor protein-cleaving enzyme|memapsin-2|membrane-associated aspartic protease 2|transmembrane aspartic proteinase Asp2
Swissprots Q9UJT5 Q9BYB9 E9PE65 P56817 B0YIU9 Q9ULS1 Q9BYC0 Q9BYC1 A0M8W7 H7BXJ9
Accessions AAO23912 AAY16982 ACA05927 CAI61888 EAW67308 EAW67309 EAW67310 EAW67311 EAW67312 EAW67313 EAW67314 EAW67315 EAW67316 EAW67317 P56817 AB032975 BAA86463 AB050436 BAB40931 AB050437 BAB40932 AB050438 BAB40933 AB089958 BAC81826 AB177847 BAD66825 AF161367 AAF28927 AF190725 AAF04142 AF200193 AAF13715 AF200343 AAF17079 AF201468 AAF18982 AF204943 AAF26367 AF324837 AAM54050 AF338816 AAK38374 AF338817 AAK38375 AF527782 AAM92013 AK075049 BAG52056 AK296015 BAH12238 AK296535 BAH12380 AL833810 CAD38674 BC036084 AAH36084 BC065492 AAH65492 BM996673 BQ005204 DC343475 DQ891509 ABM82435 DQ894700 ABM85626 NM_001207048 NP_001193977 NM_001207049 NP_001193978 NM_012104 NP_036236 NM_138971 NP_620427 NM_138972 NP_620428 NM_138973 NP_620429
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}.
Subcellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Tissue Specificity Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:11083922}.
Top Pathways Alzheimer's disease

BACE CRISPR/Cas9 KO Plasmid (h) - sc-401500 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE HDR Plasmid (h) - sc-401500-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE Double Nickase Plasmid (h) - sc-401500-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE Double Nickase Plasmid (h2) - sc-401500-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE CRISPR Activation Plasmid (h) - sc-401500-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE CRISPR Activation Plasmid (h2) - sc-401500-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE Lentiviral Activation Particles (h) - sc-401500-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE Lentiviral Activation Particles (h2) - sc-401500-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BACE siRNA (h) - sc-37224 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BACE shRNA Plasmid (h) - sc-37224-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BACE shRNA (h) Lentiviral Particles - sc-37224-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BACE-1 RNAi - H00023621-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BACE-1 RNAi - H00023621-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU087231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1005 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1005 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BACE1 siRNA (Human) - CRH8402 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BACE-1 RNAi - H00023621-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

BACE-1 RNAi - H00023621-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BACE1 - MBS8226367 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BACE1 (NM_138973.3) - SHH244562 from Creative biogene

Category siRNA
Species Reactivities Human

Human BACE1 siRNA - orb268904 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BACE1 shRNA Plasmid (Human) - CHH8402 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BACE1 miRNA 3'UTR clone - MiUTR3H-06677 from Creative biogene

Species Reactivities Human
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