LYN

Gene Symbol	LYN
Entrez Gene	4067
Alt Symbol	JTK8, p53Lyn, p56Lyn
Species	Human
Gene Type	protein-coding
Description	LYN proto-oncogene, Src family tyrosine kinase
Other Description	lck/Yes-related novel protein tyrosine kinase|tyrosine-protein kinase Lyn|v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Swissprots	A0AVQ5 P07948
Accessions	EAW86764 EAW86765 EAW86766 EAW86767 EAW86768 P07948 AK130135 AK290494 BAF83183 AK298677 BAG60841 BC059394 AAH59394 BC068551 AAH68551 BC075001 AAH75001 BC075002 AAH75002 BC126456 AAI26457 BC126458 AAI26459 BG059526 BU954348 CB990993 CN480554 DA948647 M16038 AAA59540 M79321 AAB50019 XM_011517529 XP_011515831 XM_011517530 XP_011515832 XM_011517531 XP_011515833 XR_928779 NM_001111097 NP_001104567 NM_002350 NP_002341
Function	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and
Subcellular Location	Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
Tissue Specificity	Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors. {ECO:0000269|PubMed:3561390, ECO:0000269|PubMed:8064233}.
Top Pathways	Fc gamma R-mediated phagocytosis, Epstein-Barr virus infection, Viral carcinogenesis, Chemokine signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LYN ELISA Kit (Sandwich ELISA) - LS-F7221 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.062 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-LYN (Tyr507) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1090 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat LYN ELISA Kit (Cell-Based ELISA) - LS-F2120 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Phosphotyrosine LYN / Tyrosine-protein Kinase Lyn ELISA Kit - RAB0976 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Phospho-Lyn (Y397) DuoSet IC ELISA, 2 Plate - DYC3936-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 15.60 - 1,000 pg/mL

Human LYN ELISA Kit - abx152250 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Tyrosine-protein kinase Lyn (LYN), Human, ELISA Kit - CSB-EL013259HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN), Human, ELISA Kit - SEG523Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.062ng/mL Range 0.156-10ng/mL

LYN (Human) IP-WB Antibody Pair - H00004067-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN), ELISA Kit - MBS2023647 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human LYN is typically less than 0.062ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

Lyn Colorimetric Cell-Based ELISA Kit - CB5419 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Lyn (Phospho-Tyr507) Colorimetric Cell-Based ELISA Kit - CBP1069 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS055153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, ELISA Kit - MBS938909 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human LYN is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS052908 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS052912 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS089044 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS063967 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS052965 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, ELISA Kit - MBS102886 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) - SEG523Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Tyrosine-protein kinase Lyn(LYN) ELISA kit - CSB-EL013259HU from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml. Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) - SEG523Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) ELISA Kit - EKU08197 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.062 ng/mL Range 0.156-10 ng/mL

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN), Human, ELISA Kit - DL-LYN-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

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