LYN
| Gene Symbol | LYN |
|---|---|
| Entrez Gene | 4067 |
| Alt Symbol | JTK8, p53Lyn, p56Lyn |
| Species | Human |
| Gene Type | protein-coding |
| Description | LYN proto-oncogene, Src family tyrosine kinase |
| Other Description | lck/Yes-related novel protein tyrosine kinase|tyrosine-protein kinase Lyn|v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| Swissprots | A0AVQ5 P07948 |
| Accessions | EAW86764 EAW86765 EAW86766 EAW86767 EAW86768 P07948 AK130135 AK290494 BAF83183 AK298677 BAG60841 BC059394 AAH59394 BC068551 AAH68551 BC075001 AAH75001 BC075002 AAH75002 BC126456 AAI26457 BC126458 AAI26459 BG059526 BU954348 CB990993 CN480554 DA948647 M16038 AAA59540 M79321 AAB50019 XM_011517529 XP_011515831 XM_011517530 XP_011515832 XM_011517531 XP_011515833 XR_928779 NM_001111097 NP_001104567 NM_002350 NP_002341 |
| Function | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and |
| Subcellular Location | Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts. |
| Tissue Specificity | Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors. {ECO:0000269|PubMed:3561390, ECO:0000269|PubMed:8064233}. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Epstein-Barr virus infection, Viral carcinogenesis, Chemokine signaling pathway, B cell receptor signaling pathway |
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