LYN

Gene Symbol	LYN
Entrez Gene	4067
Alt Symbol	JTK8, p53Lyn, p56Lyn
Species	Human
Gene Type	protein-coding
Description	LYN proto-oncogene, Src family tyrosine kinase
Other Description	lck/Yes-related novel protein tyrosine kinase|tyrosine-protein kinase Lyn|v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Swissprots	A0AVQ5 P07948
Accessions	EAW86764 EAW86765 EAW86766 EAW86767 EAW86768 P07948 AK130135 AK290494 BAF83183 AK298677 BAG60841 BC059394 AAH59394 BC068551 AAH68551 BC075001 AAH75001 BC075002 AAH75002 BC126456 AAI26457 BC126458 AAI26459 BG059526 BU954348 CB990993 CN480554 DA948647 M16038 AAA59540 M79321 AAB50019 XM_011517529 XP_011515831 XM_011517530 XP_011515832 XM_011517531 XP_011515833 XR_928779 NM_001111097 NP_001104567 NM_002350 NP_002341
Function	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and
Subcellular Location	Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
Tissue Specificity	Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors. {ECO:0000269|PubMed:3561390, ECO:0000269|PubMed:8064233}.
Top Pathways	Fc gamma R-mediated phagocytosis, Epstein-Barr virus infection, Viral carcinogenesis, Chemokine signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Lyn full length protein - ab60306 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human Lyn full length protein - ab70789 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Lyn full length protein - ab139777 from Abcam Category Protein Source E. coli Species Human

Lyn (phospho Y396) peptide - ab202645 from Abcam Category Peptide

LYN Antibody Blocking Peptide - LS-E3444 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LYN Antibody Blocking Peptide - LS-E19712 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LYN Antibody Blocking Peptide - LS-E19713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LYN Antibody Blocking Peptide - LS-E9216 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LYN Antibody Blocking Peptide - LS-E26666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Lyn Partial Recombinant Protein - H00004067-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lyn Recombinant Protein - H00004067-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Lyn Protein - NBP2-22945 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Lyn Recombinant Protein - P4199 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Lyn Recombinant Protein - P4715 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Lyn Protein - NBP1-99483 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Lyn Peptide - P2756 from Novus Biologicals Category Peptide Species Human

LYN-Antibody-N-term-Blocking-Peptide - BP7713a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LYN blocking peptide - GTX88717-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Recombinant Human Active Lyn B, CF - 3206-KS-010 from R&D Systems Category Protein

Human LYN GST tag protein - orb83906 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

Human CIRBP protein - orb81204 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Lyn Blocking Peptide - 33R-7557 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LYN Blocking Peptide - 33R-2118 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LYN protein (His tag) - 80R-2622 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

Human LYN Protein - abx069701 from Abbexa Category Protein Source E.coli Species Human

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