| Gene Symbol |
USP28
|
| Entrez Gene |
57646
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 28
|
| Other Description |
deubiquitinating enzyme 28|ubiquitin carboxyl-terminal hydrolase 28|ubiquitin carboxyl-terminal hydrolase 28 variant 1|ubiquitin specific protease 28|ubiquitin thioesterase 28|ubiquitin thiolesterase 28|ubiquitin-specific-processing protease 28
|
| Swissprots |
Q96RU2 B0YJC0 Q6NZX9 Q9P213 B0YJC1
|
| Accessions |
ACA06098 ACA06099 CCQ43656 EAW67231 EAW67232 EAW67233 EAW67234 EAW67235 Q96RU2 AB040948 BAA96039 AF266283 AAK58565 AK027521 BAB55172 AK097623 AK304376 BAG65214 AK304770 BAG65525 BC035986 BC065928 AAH65928 BF434481 BU940680 CD704003 DB061316 XM_005271630 XP_005271687 XM_005271631 XP_005271688 XM_005271632 XP_005271689 XM_005271633 XP_005271690 XM_005271636 XP_005271693 XM_005271637 XP_005271694 XM_005271638 XP_005271695 XM_005271639 XP_005271696 XM_011542936 XP_011541238 XM_011542937 XP_011541239 XM_011542938 XP_011541240 XM_011542939 XP_011541241 XM_011542940 XP_011541242 XM_011542941 XP_011541243 XM_011542942 XP_011541244 NM_001301029 NP_001287958 NM_020886 NP_065937
|
| Function |
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}.
|